High-sensitivity troponin T
Conditions
Interventions
Sixty patients will be randomized to receive adenosine or placebo (distilled water) immediately before the infusion of the cardioplegic solution (del Nido), with 30 participants in each group. Blood s
Sponsors
Hospital Nossa Senhora da Conceição
Hospital Nossa Senhora da Conceição
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All patients undergoing elective surgery for simple valve replacement or myocardial revascularization with extracorporeal circulation at Hospital Nossa Senhora da Conceição, Porto Alegre, aged 18 years or older, in accordance with the Informed Consent Form.
Exclusion criteria
Exclusion criteria: The following cases will be excluded from the study: previous cardiac surgery; chronic renal failure (serum creatinine greater than 2.0 mg/dl); severe psychiatric illness; urgent or emergency situations; multiple surgeries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-sensitivity troponin at baseline (patient admission to the operating room) and at 2, 12, and 24 hours after aortic clamp deployment.;VIS calculation immediately after the end of surgery and 12 and 24 hours after aortic clamp deployment.;Assessment of myocardial protection by transesophageal echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of adenosine addition on myocardial protection during extracorporeal circulation in the prevention of major cardiovascular events.;Progression of the blood gas and complete blood count curve, lactate, C-reactive protein, blood glucose, and electrolytes, determined through laboratory evaluation of arterial blood samples collected preoperatively and at 2, 12, and 24 hours after the end of cardiopulmonary bypass.;Use of mechanical circulatory support | — |
Countries
Brazil
Contacts
Public ContactCarolina Dutra
Hospital Nossa Senhora da Conceição
Outcome results
None listed