Gonarthrosis
Conditions
Interventions
This is a randomized, prospective, double-blind, six-arm clinical trial. A total of 60 patients with osteoarthritis (OA) will be selected for this study, including: a) 20 patients with knee osteoarthr
b) 20 patients with hip osteoarthritis
and c) 20 patients with spinal osteoarthritis. Within each osteoarthritis group, patients will be randomized using specific software to receive bone marrow (10 patients) or concentrated bone marrow (1
Sponsors
Instituto de Ensino Superior de Indaiatuba LTDA
Instituto do Osso e da Cartilagem - IOC
Eligibility
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: Both sexes; aged between 30 and 80 years; and having diagnosed osteoarthritis and classified according to an X-ray report; patients with moderate to severe osteoarthritis (III and IV)
Exclusion criteria
Exclusion criteria: Presenting osteoathritis of another origin and/or another degree according to the classifications mentioned above; presenting systemic diseases such as diabetes; rheumatoid arthritis; axial deviation (varus higher than 5 degrees, valgus higher than 5 degrees); hematologic diseases; cardiovascular diseases; infections; and immunosuppression; patients undergoing anticoagulant or antiplatelet therapy; use of nonsteroidal anti-inflammatory drugs 5 days before each blood collection; and patients with a hemoglobin concentration below 11 mg/dL and platelet count below 150,000 mm³
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect to see a reduction in pain assessed by the visual analog pain scale (VAS), improvement in the function of the joint verified through functional scores | — |
Secondary
| Measure | Time frame |
|---|---|
| An improvement in the function health quality evaluated through Short-Form-36 (SF-36) | — |
Countries
Brazil
Contacts
Public ContactJosé Fabio Lana
Orthoregen - Ensino e Pesquisa Em Medicina Regenerativa do Aparelho Locomotor LTDA
Outcome results
None listed