Anesthetics
Conditions
Interventions
This is a randomized, double-blind, placebo-controlled Phase IV clinical study, with two drugs in healthy adult patients undergoing surgical procedures, to investigate and compare the short-term affec
Sponsors
Departamento de Anestesiologia da Faculdade de Medicina de Botucatu
Faculade de Medicina de Botucatu - Universidade Estadual Paulista
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Both genders; age range between 18 and 65 years old; classified according to surgical risk as ASA 1 or ASA 2 or ASA 3; according to medical assessment based on health history, physical examination and laboratory tests; subjected to previously scheduled surgery, and may or may not be hospitalized with general anesthesia
Exclusion criteria
Exclusion criteria: Physical or intellectual inability to respond to the questionnaires, as assessed by the researchers; Illiterate; patients who have a previous history of an allergic reaction to opioids; chronic opioid users; users of psychoactive drugs for recreational use; patients with nephropathy, pacemakers and beta blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate and compare the short-term affective effects of the following opioids: morphine and methadone administered to patients before anesthetic induction | — |
Secondary
| Measure | Time frame |
|---|---|
| Identify predictors of postoperative opioid use and chronic postoperative pain | — |
Countries
Brazil
Contacts
Public ContactFlávia Domingues
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista
Outcome results
None listed