Evaluation of the effect of Teriparatide associated with increased bone quantity on preservation of the root cavity after tooth extraction: a randomized split-mouth clinical study

Evaluation of the effect of Teriparatide associated with xenogenous graft on post-extraction alveolar preservation: a randomized split-mouth clinical study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

REBEC

Registry ID

RBR-6jvvp9t

Enrollment

Unknown

Registered

2025-09-29

Start date

2024-09-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Resorption

Interventions

This is a randomized, controlled, triple-blind, split-mouth clinical trial. A total of 20 individuals who meet the eligibility criteria will be probabilistically allocated to one group or another usin

D06.472.699.590.850

Eligibility

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients of both genders between; 18 and 70 years old; healthy; with an indication for the extraction of two contralateral posterior teeth in the mandible or maxilla; having teeth adjacent to the extraction site

Exclusion criteria

Exclusion criteria: Presence of Acute Periapical/Periodontal Infection (Abscesses); presence of Periodontal Sisease; use of medications such as Chemotherapy, Anticoagulants, Corticosteroids, Anti-resorptive drugs (Bisphosphonates or RANKL modulators) and Immunosuppressive drugs; systemic use of Teriparatide; decompensated chronic diseases (e.g. Hypertension, diabetes, Rheumatological, Renal and Hepatic diseases); history of Anxiety, Mood, Eating and/or Psychotic Disorders that could compromise their participation and collaboration in the study; metabolic bone diseases (Osteomalacia, Hypocalcemia, Hypercalcemia, Osteoporosis); motor dysfunction that makes oral hygiene impossible or difficult; smokers; pregnant women; radiotherapy in the last 5 years

Design outcomes

Primary

Measure	Time frame
A higher alveoli preservation after tooth extraction is expected in the intervention group, verified by measuring bone availability via tomography after the bone grafting procedure in both groups.	—

Secondary

Measure	Time frame
An increase in newly formed bone is expected in the intervention group, verified through histological analysis after the bone grafting procedure in both groups.;Higher primary and secondary stability of the implants placed in the intervention group is expected, as verified through the resonance frequency immediately after implant installation and 45 days after implantation.	—

Countries

Brazil

Contacts

Public ContactHassan Saleh

Instituto Latino Americano de Pesquisa e Ensino Odontológico

hasaleh@uol.com.br+55 (47) 988215248

Outcome results

None listed

Source: REBEC (via WHO ICTRP)