Patients with obesity and insulin resistance, according to the HOMA-IR index.
Conditions
Interventions
Cross-sectional study, with 23 participants, and oral supplementation of Pera orange juice for 15 days and Moro orange juice, also for 15 days, with 200 ml at lunch and 200 ml at dinner. Between inter
Dietary supplement
G07.203.300.456
Sponsors
Faculdade de Ciências Farmacêuticas
Fundo de Defesa da Citricultura
Eligibility
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age between 40 and 60 years, both genders, with nutritional diagnosis of obesity according to the World Health Organization classification (2000) and with diagnosis of insulin resistance according to the HOMA-IR index.
Exclusion criteria
Exclusion criteria: Inflammatory diseases in the gastrointestinal tract, use of supplements or antibiotics and inability to respond to research questionnaires or to perform nutritional status assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of the production of inflammatory cytokines and chemokines after stimulation, measured through quantification tests, in any percentage.;Reduction of phagocytosis and chemotaxis in monocytes, verified through cell culture analyzes, in any percentage.;Increased activity of the antioxidant enzymes catalase, superoxide dismutase and glutathione peroxidase, by testing antioxidant activity, in any percentage.;Reduction of lipid peroxidation markers (8-isoprostanes) and DNA damage (8-OHdG), measured using the ELISA method, in any percentage. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of body weight, through measurement on a scale, in any percentage;Reduction of fasting blood glucose, measured by biochemical examination, to <99 mg / dL;Improvement of the lipid profile, measured by biochemical examination, to the respective values: total cholesterol <190 mg / dL, LDL <100 mg / dL and triglycerides <150 mg / dL);Blood pressure reduction, measured in an automatic pressure device, pulse, to values ??<120 mmHg for systolic blood pressure and <90 mmHg for diastolic blood pressure | — |
Countries
Brazil
Contacts
Public ContactNeuza Hassimotto
Faculdade de Ciências Farmacêuticas
Outcome results
None listed