Evaluation of the association of Antimicrobial Photodynamic Therapy (aPDT) with standard oral hygiene with 0.12% Chlorhexidine in the oral disinfection of critically ill patients

Evaluation of the association of Antimicrobial Photodynamic Therapy (aPDT) with Standard Therapy with 0.12% Chlorhexidine in the Oral Disinfection of critically ill patients under mechanical ventilation: a controlled and randomized study - aPDT Antimicrobial Photodynamic Therapy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

REBEC

Registry ID

RBR-6h72wkn

Enrollment

Unknown

Registered

2024-08-21

Start date

2022-10-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Hygiene

Interventions

This is a randomized, unmasked clinical study with two groups: an experimental group with 25 participants and a control group also with 25 participants. Both groups will have a swab and 1mL of initial

E02.774

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years of age; both sexes; patients undergoing orotracheal intubation for at least 72 hours; signing an informed consent form

Exclusion criteria

Exclusion criteria: Prospect of death in less than 24 hours or palliative care; patients in the immediate or late postoperative period after head surgery and neck; known allergy to any component of the chlorhexidine formula or to curcuminoids; patients with a history of oropharyngeal neoplasia; trauma patients with facial bone fractures; previous participation in the study

Design outcomes

Primary

Measure	Time frame
Decrease in Colony Forming Units (CFUs) in the culture of swabs collected before and after the procedure	—

Secondary

Measure	Time frame
Identification of the main agents of the oral microbial flora, using the MALDI-TOF technique;To evaluate the levels of interleukin-6 in saliva using the ELISA technique	—

Countries

Brazil

Contacts

Public ContactFlávio de Freitas

Departamento De Anestesiologia, Dor e Medicina Intensiva

flaviogrf@gmail.com+55-11-991866551

Outcome results

None listed

Source: REBEC (via WHO ICTRP)