Sickle-cell disorders
Conditions
Interventions
The intervention consisted of inspiratory muscle training (IMT) that was applied both in the group undergoing training with false load (SG) and in the other group was called intervention group (TG), w
the 6-minute walk test (6MWT) was performed with blood lactate concentration (Lac) assessment, using a lactimeter pre and post 6MWT. IMT was performed at the patients home through the inspiratory moti
Device
C15.378.071.141.150.150.440
E01.370.386.700.150
Sponsors
Hemocentro - Universidade Estadual de Campinas
Hemocentro - Universidade Estadual de Campinas
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Have a diagnosis of sickle cell disease; of both genders; be between 18 and 70 years old; present a stable clinical condition of the disease.
Exclusion criteria
Exclusion criteria: Present neurological or traumatic sequelae that make it impossible to properly perform any of the assessment items; presenting neurological or traumatic sequelae that make it impossible to properly perform inspiratory muscle training; present any lung disease that is not related to sickle cell disease and that may alter the appropriate performance of any of the assessment items.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected result 1: Increase in inspiratory and expiratory muscle forces in the intervention group with real load (TG) compared to the group that performed the training with false load (SG) after the intervention period.;Outcome found 1: Statistically significant increase (p <0.05) of inspiratory and expiratory muscle forces in the comparison between the initial and the final evaluation, both in the intervention group with real load (TG) and in the group that performed the training with false load (SG).;Expected outcome 2: Improvement of the variables evaluated in spirometry in the intervention group with real load (TG) in relation to the group that performed the training with false load (SG) after the intervention period.;Outcome found 2: Statistically significant increase (p <0.05) of the spirometric variables forced expiratory flow in the first second, Tiffeneau index and average forced expiratory flow in the comparison between pre and post bronchodilator evaluation, both in the initial evaluation and in the final evaluation in both groups, but no significant changes were observed in the comparison between the initial and final evaluations.;Expected outcome 3: Improvement of the variables assessed in the volumetric capnography in the intervention group with real load (TG) compared to the group that performed the training with false load (SG) after the intervention period.;Outcome found 3: Of the variables assessed in volumetric capnography, the inspiratory time (Ti) was significantly longer in the group that performed the training with false load (SG) compared to the intervention group with real load (TG) (p <0.05, group effect). However, the following variables: inspiratory tidal volume (Vi), peak expiratory flow (PEF), phase 3 slope of the capnography curve (P3Slp), phase 3 slope normalized according to expired tidal volume (P3Slp / Ve ), peak inspiratory flow (PIF) and Tobin Index (RSBI) showed significant changes in relation to the effect of time in both group | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Secondary outcomes were not expected in relation to inspiratory and expiratory muscle forces.;Outcome found 1: The group that performed the training with false load (SG) also obtained a statistically significant increase (p 0.05 in all variables when comparing the pre-intervention period with the post-intervention period in the intervention group with real load (TG).;Expected outcome 3: Secondary outcomes were not expected in relation to the variables assessed in volumetric capnography.;Outcome found 3: The group that performed the training with false load (SG) had a statistically significant longer inspiratory time (Ti) (p 0.05.;Expected outcome 6: No secondary outcome was expected in relation to the limitation imposed by dyspnea on activities of daily living after the intervention period.;Outcome found 6: The group that performed training with false load (SG) showed a significant reduction (p 0.05. | — |
Countries
Brazil
Contacts
Public ContactSara Saad
Hemocentro - Universidade Estadual de Campinas
Outcome results
None listed