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Effect of bicarbonate anesthesia on mandibular molars

Anesthetic effect of 4% and 2% alkalized Articaine for infiltrative anesthesia in mandibular molars

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
REBEC
Registry ID
RBR-6fsprpc
Enrollment
Unknown
Registered
2022-06-28
Start date
2021-08-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Toothache

Interventions

For the present two-arm randomized clinical trial (articaine 4% and articaine 2% alkalized) the sample will be composed of 42 students from the second to the fifth year of graduation and post-graduati

Sponsors

Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas
Lead Sponsor
Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas
Collaborator

Eligibility

Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Healthy individuals; Age 18 years or older; Previous experience of local anesthesia (have already taken it on another occasion); No history of complications resulting from local anesthesia; Lower molars on both sides healthy (absence of restorations); Responsible for the electrical stimulus “Pulp Tester”.

Exclusion criteria

Exclusion criteria: Pregnant women; lactating women; with systemic involvement that would contraindicate anesthesia; History of allergic reaction to any component of the anesthetic solutions used; Presence of an inflammatory condition in the region.

Design outcomes

Primary

MeasureTime frame
The anesthetic efficacy of alkalized 2% articaine solution is expected to be equal to or greater than commercial 4% articaine solution. Through the esthesiometer to assess latency and duration of soft tissue anesthesia, pulp tester to assess latency and duration of pulp anesthesia and through the visual analogue scale to compare pain and burning sensation during the injection of both solutions.

Secondary

MeasureTime frame
We do not expect secondary outcomes

Countries

Brazil

Contacts

Public ContactSidney Raimundo

Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas

sfigeuroba@uol.com.br+55 19 2106-5310

Outcome results

None listed

Source: REBEC (via WHO ICTRP)