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Effects of prolonged exercise on metabolic changes in insulin, inflammation and oxidation in morbidly obese subjects

Effects of chronic physical exercise of moderate intensity on insulin signaling pathways, inflammation and oxidative stress in individuals with morbid obesity

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-6frnzp
Enrollment
Unknown
Registered
2018-06-05
Start date
2011-03-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eutrophication

Interventions

Control group, composed of 20 eutrophic volunteers, submitted to moderate exercise. Diet group, composed of 20 volunteers with morbid obesity, submitted to a balanced restrictive diet. Diet and exerci
Other
G11.427.410.698.277
E02.570
E02.760.169.063.500.387

Sponsors

Universidade Estadual de Campinas
Lead Sponsor
Universidade Estadual de Campinas
Collaborator

Eligibility

Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Adults between 18 and 60 years of both sexes; availability and physical conditions to perform the tests and supervised physical exercises (control group and obese subjects submitted to physical exercise); availability to perform dietary restriction and physical inactivity (obese group submitted only to the restrictive diet) during the study period; inactive for at least 30 days (less than 150 minutes of moderate physical activity per week); no restrictive diet in the last 30 days; no use of medications for weight loss or modulation of body composition for at least 3 months; stable weight at least 3 months

Exclusion criteria

Exclusion criteria: Individuals with or having a first-degree history of cardiovascular diseas; hepatic impairmen; renal impairment; diabetes; thyroid disorders; menopausal women; pregnant women; nursing mothers; smokers; or in continuous use of any medications

Design outcomes

Primary

MeasureTime frame
Weight loss around 10% of the diet and exercise group of obesity in the pre and post intervention measurements;Reduction of the body fat percentage of both groups measured through the bioimpedance result pre and post intervention measurements;Improvement of biochemical parameters related to inflammation and oxidative stress (catalase, superoxide desmutase, glutathione, tumor necrosis factor, interleukin-6) in the pre and post intervention measurements;Reduced insulin resistance (HOMA-IR) pre and post intervention measurements—

Secondary

MeasureTime frame
Secondary outcomes are not expected—

Countries

Brazil

Contacts

Public ContactSarah Alegre

Universidade Estadual de Campinas

salegre@fcm.unicamp.br+5501935217155

Outcome results

None listed

Source: REBEC (via WHO ICTRP)