Heart Failure
Conditions
Interventions
Intervention Group (IG n=41): will undergo a supervised combined exercise program consisting of continuous walking type aerobic exercise plus strength exercise for 16 weeks, three times a week, for 45
Other
Sponsors
Hospital das Clínicas da Faculdade de Medicina de Botucatu
Faculdade de Medicina de Botucatu (FMB) - Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP)
Eligibility
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Will be included participants older than 18 years; both sexes; heart failure with reduced ejection fraction (HFrEF) of various etiologies and optimized drug therapy.
Exclusion criteria
Exclusion criteria: Patients with heart failure grade III and IV and stage D; Hypertrophic cardiomyopathy; Deposit diseases; Mitral and aortic stenosis; Decompensated heart failure in the last three months; Persistent or permanent atrial fibrillation and/or artificial pacemaker rhythm; Chronic obstructive pulmonary disease; Biomechanical limitations that prevent them from participating in the proposed combined physical exercise program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a) Echocardiographic cardiac evaluation: 20% improvement of left ventricular diastolic and systolic function; ;b) Evaluation of circulating miRNAs: assess the profile as biomarkers to monitor the treatment of heart failure; ;c) Evaluation of plasma BNP concentration: 30% reduction after intervention; ;d) Evaluation of plasma nitrite / nitrate concentration: 30% increase after intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| a) Evaluation of inflammatory cytokines: improvement of inflammatory response in the range of 30 to 50% after the intervention; ;b) Handgrip assessment: increase after intervention;;c) Assessment of functional capacity: improvement at or above 300 meters in the Cooper Walking or Running Test 12 minutes the following week after 16 weeks of intervention;;d) Quality of life assessment: 15% improvement in perception on the quality of life scale after the intervention;;e) Bioimpedance assessment: improvement in the range of 5 to 10% of the total body fat index after the intervention. | — |
Countries
Brazil
Contacts
Public ContactSilméia Zanati Bazan
Faculdade de Medicina de Botucatu - UNESP
Outcome results
None listed