Subclinical hypothyroidism
Conditions
Interventions
Experimental group: 24 individuals between 18 and 65 years with subclinical hypothyroidism, will use metformin 850 mg twice daily for a period of three months.
Control group: 24 individuals between 18
Drug
Sponsors
Hospital de Clínicas de Porto Alegre - UFRGS
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Volunteers of both sexes; aged between 18 and 65; with TSH greater than the upper limit of normal for the method in two steps, the first by any method and the second measured by chemiluminescence accompanied by free T4 levels within normal limits.
Exclusion criteria
Exclusion criteria: Previous diagnosis of type 2 diabetes; use of levothyroxine; contraindications to the use of metformin; known abnormal liver function; heart failure NYHA III-IV despite optimal drug therapy; serious mental illness; any terminally ill; malignancy not cured or in treatment; contrast studies in the last three months; use of medications known to interfere with thyroid function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Down 0.5 microUI / mL in TSH levels measured by chemiluminescence. | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients achieving euthyroid state, checked by normalizing the TSH levels. | — |
Countries
Brazil
Contacts
Public ContactBeatriz Schaan
Hospital de Clínicas de Porto Alegre - UFRGS
Outcome results
None listed