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Effect of periodontal treatment on blood vessels and inflammation in type 2 diabetics with gum disease

Effect of periodontal treatment on endothelial and microvascular functions and gingival fluid and blood levels of immunoinflammatory biomarkers in type 2 diabetics with severe periodontitis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-69yzkb
Enrollment
Unknown
Registered
2015-02-19
Start date
2014-08-11
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus, severe periodontitis

Interventions

Test group: 30 diabetic patients will receive nonsurgical periodontal treatment, namely oral hygiene instruction, supragingival and subgingival scaling. Control group: 30 diabetic patients will receiv
Procedure/surgery
E06.721.189.675
E06.721.189.350

Sponsors

Hospital Universitário Pedro Ernesto
Lead Sponsor
Faculdade de Odontologia da UERJ
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients with severe periodontitis; both genders; more than 18 years old; at least 12 teeth; type 2 diabetes mellitus

Exclusion criteria

Exclusion criteria: HIV; immunological and chronic inflammatory diseases; prolonged usage of medications 6 months before the start of the study as antibiotics; cortisone; antihistamine; hormones; and others

Design outcomes

Primary

MeasureTime frame
Mean differences in endothelial and microvascular functions evaluated by videocapillaroscopy and pletismography pre and post intervention—

Secondary

MeasureTime frame
Differences in gingival fluid and blood levels of immunoinflammatory biomarkers evaluated by multiplex pre and post intervention—

Countries

Brazil

Contacts

Public ContactRonaldo;Ronaldo Lira;Lira Júnior

Faculdade de Odontologia da UERJ;Faculdade de Odontologia da UERJ

lira_jr@hotmail.com;lira_jr@hotmail.com+55 (21) 2868 8282;+55 (21) 2868 8282

Outcome results

None listed

Source: REBEC (via WHO ICTRP)