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Comparison of arterial blood pressure drop after fast and slow infusion of propofol during general anesthesia

Comparison of the incidence of arterial hypotension between propofol in target controlled infusion and bolus injection during induction of general anesthesia in young adults and non-cardiac surgeries - Randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
REBEC
Registry ID
RBR-69px3cj
Enrollment
Unknown
Registered
2022-06-23
Start date
2019-08-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension

Interventions

Patients admited for elective non-cardiac surgery will be randomized into two groups according to online random number generator. 30 patients will be allocated in each group. In the first group, anest

Sponsors

Universidade de Brasília
Lead Sponsor
Faculdade de Medicina da Universidade de Brasília
Collaborator

Eligibility

Age
35 Years to 55 Years

Inclusion criteria

Inclusion criteria: 35 to 55 year-old patients; elective surgery under general anesthesia; orotracheal intubation using direct laringoscopy; physical status I or II according to American Society of Anesthesiology classification

Exclusion criteria

Exclusion criteria: Data loss; infusion of drugs or doses out of the protocol; painful stimulus during protocol; refusal to participate

Design outcomes

Primary

MeasureTime frame
Incidence of hypotension after anesthesia induction with propofol in bolus infusion or target controlled infusion, measured by mean and standart deviation of mean arterial pressures, considering a reduction of at least 20% in the mean arterial pressures before and after induction.

Secondary

MeasureTime frame
Variation of mean arterial pressure, heart rate, bispectral index and supression rate during the first 10 minutes of anestesia induction, measured by mean and standart deviation of the results in both groups

Countries

Brazil

Contacts

Public ContactAna Vale

Universidade de Brasília

anaggvale@gmail.com+55 61 995514004

Outcome results

None listed

Source: REBEC (via WHO ICTRP)