Photobiomodulation in the prevention of induced Trissum by head and neck Radiotherapy

Influence of Photobiomodulation in the prevention of induced Trissum by head and neck Radiotherapy: triple blind clinical test, randomized and controlled placebo

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

REBEC

Registry ID

RBR-67qxnt9

Enrollment

Unknown

Registered

2025-04-16

Start date

2022-07-13

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trismus

Interventions

This is a phase II, randomized, triple-blind, placebo-controlled clinical trial.Both groups will receive the photobiomodulation protocol equally, but in the control group the simulation will be perfor

totaling 270 seconds of application and 24 J energy per side, the extraoral points will be applied near the region of the temporomandibular joint described by: (A) superior, (B) posterior and (C) ante

E02.594.540

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years of age will be included; both sexes; with head and neck cancer in the nasopharynx, maxillary sinuses, oropharynx, mouth and salivary glands; stages I, II, III or IV in which head and neck radiotherapy has been indicated

Exclusion criteria

Exclusion criteria: Patients who underwent previous surgery for tumor resection and/or neck dissection, patients Patients who have undergone previous tumor resection and/or cervical dissection surgery will be excluded; patients with tumor recurrence or recurrence; previous history of head and neck radiotherapy; patients whose radiotherapy dose is less than 40G; patients who withdraw from treatment or the study; who required a change in the therapeutic protocol; who develop extreme toxicity or evolve to death

Design outcomes

Primary

Measure	Time frame
Perform biostimulation of injured muscles during radiotherapy, since it can stimulate muscle repair, reduce inflammatory processes and regenerate lost or damaged cells in order to develop an adequate and efficient standard protocol against the use of photobiomodulation for prevention, treatment and reduction. of the degree of severity of trismus in patients undergoing radiotherapy for the treatment of head and neck cancer	—

Measure

Time frame

Perform biostimulation of injured muscles during radiotherapy, since it can stimulate muscle repair, reduce inflammatory processes and regenerate lost or damaged cells in order to develop an adequate and efficient standard protocol against the use of photobiomodulation for prevention, treatment and reduction. of the degree of severity of trismus in patients undergoing radiotherapy for the treatment of head and neck cancer

—

Secondary

Measure	Time frame
To longitudinally assess mouth opening and the incidence and severity of trismus in patients with head and neck cancer during radiotherapy treatment	—

Countries

Brazil

Contacts

Public ContactMarcela Borges

Universidade Federal do Ceará

marcelafbfranco@hotmail.com+55 (85) 996318269

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Mar 16, 2026