Hemorrhagic Stroke Nervous System Diseases
Conditions
Interventions
This is a randomized controlled experimental clinical trial with five arms including 150 participants, comprising 75 healthy individuals and 75 patients with chronic stroke, allocated into five parall
Sponsors
Universidade Federal de Alfenas
Universidade Federal de Alfenas
Eligibility
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: Individuals of both sexes; aged between 30 and 75 years; diagnosis of left ischemic stroke confirmed by computed tomography or magnetic resonance imaging; between 3 weeks and 1 year post stroke; right upper limb motor preference assessed by the Edinburgh Handedness Inventory translated and validated into Portuguese with inclusion of only right handed participants with right hemiparesis and preserved right handgrip function; minimum score of 27 points in the upper limb domain of the Fugl Meyer scale
Exclusion criteria
Exclusion criteria: Left sided motor preference assessed by the Edinburgh Handedness Inventory; orthopedic disorders; contraindications to repetitive transcranial magnetic stimulation including personal or first degree family history of epilepsy or seizures presence of metallic implants or active electronic devices in the head or neck presence of cardiac pacemaker or implanted defibrillator; inability to understand written and spoken Portuguese; pain during task execution; difficulty performing handgrip or index finger flexion movements; failure to reach at least 70 percent of maximal voluntary isometric contraction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the change in motor evoked potential (MEP) amplitude, measured peak-to-peak in the first dorsal interosseous muscle, assessed using transcranial magnetic stimulation before and after the intervention, as an indicator of corticospinal excitability. Additional primary outcomes will include the MEP-based motor overflow index (calculated as the percentage change between resting and task conditions) and the force irradiation index obtained through handgrip dynamometry during standardized isometric contractions. These outcomes will be used to estimate the effect of the intervention on corticospinal excitability and motor control. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will include motor evoked potential latency and duration, measured using transcranial magnetic stimulation; handgrip strength (expressed as a percentage of maximal voluntary isometric contraction) obtained by dynamometry; and comparisons of responses between groups (healthy individuals versus patients with stroke) and across different stimulation sites (primary motor cortex, supplementary motor area, and anterior cingulate cortex). Additionally, the influence of time (pre- versus post-intervention) and laterality on neurophysiological and mechanical outcomes will be evaluated. | — |
Countries
BR
Contacts
Public ContactMarcelo Silva
Universidade Federal de Alfenas
Outcome results
None listed