Tooth Loss
Conditions
Interventions
This study is a randomized (simple randomization of flipping a coin), controlled, double-blind clinical trial. Twenty healthy participants (male or female), healthy, aged 18 years or older, with an in
A11.329.629
Sponsors
Comando da Aeronáutica
Programa de Pós Graducação em Odontologia da Universidade Federal Fluminense
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Healthy volunteers over 18 years of age; of either gender; with an indication for the extraction of premolar or molar teeth from any dental arch who have adjacent teeth present; and are willing to cooperate with the study
Exclusion criteria
Exclusion criteria: Volunteers presenting with teeth affected by acute periapical or periodontal infections (abscesses); those with severe systemic diseases or under medications such as chemotherapy, anticoagulants, corticosteroids, antiresorptive drugs, or immunosuppressive agents; patients using systemic melatonin; individuals with decompensated chronic diseases; metabolic bone disorders; any motor dysfunction that impairs or prevents proper oral hygiene; smokers (former smokers must have ceased smoking for at least 6 months); pregnant women; and patients who have undergone radiotherapy within the past 5 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome1: Melatonin incorporated into the collagen sponge in post-extraction sockets may promote new bone formation;Outcome found 1: Melatonin gel incorporated into the collagen sponge promoted bone repair in post-exodontia sockets | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes were expected | — |
Countries
Brazil
Contacts
Public ContactIngrid Kischinhevsky
Comando da Aeronáutica
Outcome results
None listed