Subarachnoid hemorrhage
Conditions
Interventions
This is a double-blinded, randomized controlled trial with two groups. Intervention group: 30 individuals with aneurysmal subarachnoid hemorrhage will receive amantadine, oral pills, administered for
100mg 12/12h week 2
150mg 12/12h week 3
200mg 12/12h following weeks. Control group: 30 individuals will receive placebo, oral pill, administered for 6 weeks: 1 pill in the morning in week 1
1 pill 12/12h for the following weeks.
D02.455.426.100.050.035
Sponsors
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Hospital Universitário Cajuru da Pontifícia Universidade Católica do Paraná
Eligibility
Inclusion criteria
Inclusion criteria: Patients with spontaneous subarachnoid hemorrhage due to cerebral aneurysm rupture; adults; both genders
Exclusion criteria
Exclusion criteria: Unfavorable previous baseline neurological status, defined as modified Rankin Scale (mRS) greater than 2; pediatric patients
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| We are expecting a reduction in disability progression, determined through the Glasgow Outcome Scale 3 and 6 months after discharge, verified through a statistically significant difference between groups.;We are expecting a reduction in mortality, verified through a statistically significant difference between groups. | — |
Primary
| Measure | Time frame |
|---|---|
| We are expecting a reduction in disability progression, determined through the Modified Rankin Scale 3 and 6 months after discharge, verified through a statistically significant difference between groups. | — |
Countries
Brazil
Contacts
Public ContactLuana Gatto
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Outcome results
None listed