Alveolar bone repair
Conditions
Interventions
A randomized, triple-blind, split-mouth clinical trial investigated the effects of a single intra-alveolar application of Teriparatide-TPTD (20 µg) incorporated into a xenogeneic collagen matrix, seal
Sponsors
Universidade Federal Fluminense
Universidade Federal Fluminense
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Individuals aged18 years or older; clinically healthy; with an indication for bilateral extraction of premolars and/or molars (from the same or different arches); with the presence of teeth adjacent to the teeth to be extracted and who agreed to participate in the study by signing the Informed Consent Form; Teeth with an indication for extraction without viability of rehabilitation
Exclusion criteria
Exclusion criteria: Presence of acute periapical or periodontal infection; serious systemic diseases; current use of medications such as chemotherapeutic agents, anticoagulants, corticosteroids, anti-resorptive agents (such as bisphosphonates and RANKL modulators) or immunosuppressants; decompensated chronic diseases (including hypertension, diabetes, rheumatological, renal or hepatic diseases); metabolic bone diseases (such as osteomalacia, hypocalcemia or hypercalcemia); motor limitations that compromise oral hygiene; active smoking (or ex-smokers with less than six months of cessation); pregnancy or history of radiotherapy in the last five years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: A difference in bone repair is expected in the alveoli that received Teriparatide – TPTD, showing greater bone density when compared to the control group, which did not receive the medication, over a period of 90 days.;Outcome found 1: Better bone repair was observed in the Test group through intra-alveolar bone volumetric analysis; a significantly higher bone volume density was also observed in the Test group in the histomorphometric analysis, corroborating the information obtained through microtomography (µCT), with a greater number of trabeculae and less separation between the trabeculae, over a period of 90 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| It has no secondary outcome. | — |
Countries
Brazil
Contacts
Public ContactRafael Bonato
Universidade Federal Fluminense
Outcome results
None listed