Atherosclerosis
Conditions
Interventions
Follow-up study, longitudinal, prospective with 345 children and adolescents with congenital heart disease. The aim of the study is to investigate the association of dietary patterns, inflammation and
E05.318.308.980
Sponsors
Universidade Federal de Santa Catarina
Universidade Federal de Santa Catarina
Hospital Universitário Polydoro Ernani de São Tiago/UFSC
Hospital Infantil Joana de Gusmão
Eligibility
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: Children and adolescents aged 5 to 18 years; of both sexes; diagnosed with congenital heart disease; underwent some type of cardiac procedure (therapeutic catheterization or cardiac surgery)
Exclusion criteria
Exclusion criteria: Secondary diagnosis, as malignant neoplasm, chromosomal abnormalities (trisomy 21, Turner, Noonan and others); primary or secondary familial dyslipidemia; diabetes mellitus; hypothyroidism; acute diseases in the last 15 days (Respiratory and gastrointestinal infections); other chronic inflammatory diseases (Lupus, hepatitis, arthritis, asthma, intestinal syndromes and others).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate subclinical atherosclerosis using the carotid intima-media thickness method, expressed in mm | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate central obesity using the waist circumference method, expressed in percentile for age and sex ;To evaluate inflammation using determination method to cytokine (IL-2, IL-4, IL-6, IL-10, tumor necrosis factor protein (TNF), Interferon-y (IFN-y) and IL-17a) using flow cytometry method, expressed in pg/mL, C-reactive protein by immunonephelometry method, expressed in mg/L, and vascular and intercellular adhesion molecules using ELISA kit, expressed in ng/mL;To evaluate dyslipidemia using lipid parameters (total cholesterol, HDL-c, LDL-C, non-HDL-c and triglycerides) using an colorimetric enzymatic method, expressed in mg/dL ;To evaluate diabetes using glycemic parameters (fasting glucose, using colorimetric enzymatic method, expressed in mg/dl, insulin, using immunometric chemiluminescence assay, expressed in µUI/mL and HOMA-IR by formula: fasting insulin x fasting glucose/22.5²);To evaluate hypertension using a standard method with mercury sphygmomanometer with an appropriately sized cuff according to the arm circumference, expressed in percentile | — |
Countries
Brazil
Contacts
Public ContactYara Maria;Michele Moreno;Honicky
Universidade Federal de Santa Catarina;
Outcome results
None listed