COVID-19
Conditions
Interventions
This is a retrospective cohort study (for patients who have already had the disease) and prospective, conducted at Hospital Evangélico de Belo Horizonte. Dialitic patients over 18 years of age, regard
•Oxygen administration and which form was used, use of medications, mode of mechanical ventilation, indication of prone position, etc.
• Outcomes such as mortality, presence of cardiovascular events (
Other
Sponsors
Associação Evangélica Beneficente de Minas Gerais
Faculdade de Medicina da Universidade Federal de Minas Gerais
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Dialytic patients from Centros de Nefrologia do Hospital Evangélico de Belo Horizonte; patients with diagnosis of COVID-19 admited in Hospital Evangélico de Belo Horizonte, older than 18 years old.
Exclusion criteria
Exclusion criteria: Refuse to sign the informed consent form, patients younger than 18 years old and vulnerable populations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total death and acute respiratory failure: Type 1 acute respiratory failure is defined when paO2 is less 60mmHg; type 2 acute respiratory failure is defined when paCO2 greater than 50mmHg and arterial pH is less than 7.35; mixed acute respiratory failure is defined when paO2 is less than 60mmHg and paCO2 is greater 50mmHg. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular death. Death due to myocardial infarction, heart failure, stroke and sudden death.;Acute respiratory failure. Hypoxemyc (PaO2 less than 60mm Hg), hypercapnic (PaCO2 greater than 50mm Hg and pH less than 7,35) and mixed (PaO2 less than 60mm Hg plus PaCO2 greater than 50mm Hg).;Cardiovascular complications: acute myocardial infarction according to the Third Universal Definition of Myocardial Infarction, stroke, defined as a neurological deficit, confirmed by computed tomography and evaluation by an neurologist or neurosurgeon.;Venous thromboembolism. Clinical or incidental deep venous thrombosis (ultrassound or computed tomography) and pulmonary embolism (angiotomography or angiography).;Orotracheal intubation. Advanced artificial airway (orotracheal tube, nasotracheal tube, tracheostomy or cricothyrostomy).;Positive COVID-19 serology. SARS-Cov-2 antibodis (IgM or IgG).;Chest x-ray patern. Ground glass, crazy pavy, consolidation or pleural effusion.;Chest tomography patern. Ground glass, crazy pavy, consolidation, pleural effusion or any other patern suggestive of viral penumonia.;Electrocardiogram patern. Repolarization changes in EKG, corrected QT interval, atrioventricular block, bundle brach block, etc.;Echocardiogram patern. Descriptive analysis of heart.;Serologic alterations in renin-angiotensin-aldosterone components (angiotensin II, 1-7 angiotensin, angiotensin converter enzime 1 and 2.;Serologic alterations in inflamatory cytokines (IL-1 beta, IL-6, IL-8, IL-10, TNF, IL-12p70, IL-8, RANTES, MIG, MCP-1 e IP-10). | — |
Countries
Brazil
Contacts
Public ContactGabriel Carmo
Associação Evangélica Beneficente de Minas Gerais
Outcome results
None listed