Atrophic Maxilla
Conditions
Interventions
This is a randomized controlled clinical study, double-blind. Both the researchers who will evaluate the outcomes and the participants will not know which group each participant belongs to. The proced
Group 2 (experimental) - 10 maxillary sinuses grafted with hydroxyapatite (70%) + ß-tricalcium phosphate (30%)
Group 3 (experimental) - 10 maxillary sinuses grafted with hydroxyapatite (70%) + ß-tricalcium phosphate (30%) associated with i-PRF (1:1)
Group 4 (experimental) - 10 maxillary sinuses grafted with hydroxyapatite (70%) + ß-tricalcium phosphate (30%) associated with autogenous bone (1:1). The procedure for maxillary sinus lift will be per
Sponsors
Universidade estadual Paulista Júlio de Mesquita Filho - Campus Araraquara
Faculdade de Odontologia da Universidade Estadual Paulista UNESP - Araraquara
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients aged at least 18 years; both sexes; healthy; with maxillary ridge atrophy with bone height less than 5 mm
Exclusion criteria
Exclusion criteria: Smoker; uncontrolled systemic diseases; blood dyscrasias; sinus pathologies; current or previous use of medications that interfere with bone turnover; irradiated in the head and neck region; pregnant women; untreated periodontal diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone volume gain and maintenance in the maxillary sinus after grafting, assessed by comparing cone beam computed tomography scans performed preoperatively, immediately postoperatively 15 days after tooth extraction, and late postoperatively after six months. Bone volume was calculated using three-dimensional segmentation software to determine whether the use of hydroxyapatite (70%) + ß-tricalcium phosphate (30%) associated with i-PRF promotes greater maintenance of graft volume when compared to the control group and the groups treated with hydroxyapatite (70%) + ß-tricalcium phosphate (30%) associated with autogenous bone and hydroxyapatite (70%) + ß-tricalcium phosphate (30%) alone. The difference in bone volume between the periods will be used to determine the effectiveness of each intervention in gaining and maintaining bone volume prior to the installation of dental implants. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of new bone formation and the remaining synthetic graft through histomorphometric and immunohistochemical analysis performed from biopsies collected at the time of dental implant installation, as well as the evaluation of the safety of the PlenumOss synthetic graft (hydroxyapatite (70%) + ß-tricalcium phosphate (30%)) and the different treatments investigated, through the recording of adverse events such as persistent pain, exacerbated edema, infection and dehiscence of the surgical wound throughout the patient follow-up period | — |
Countries
Brazil
Contacts
Public ContactMiguel Santos
Universidade estadual Paulista Júlio de Mesquita Filho - Campus Araraquara
Outcome results
None listed