Periodontal disease, unspecified
Conditions
Interventions
Clinical, cross-over, two-armed, double-blind, randomized controlled trial on the evaluation of the action of chlorhexidine tetrapalmitate compared to chlorhexidine digluconate in bacterial plaque and
Other
V03.175.250
Sponsors
Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara
Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara
Eligibility
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: To present a proven diagnosis of gingivitis; Presence of plaque in 30% or more of the sites; Presence of at least 5 teeth in each hemi-arch; A negative history of antibiotic use in the last six months before the study; A negative history of steroid or non-steroidal anti-inflammatory drugs in the last three months prior to or during the study.
Exclusion criteria
Exclusion criteria: Received periodontal treatment in the last 12 months; To present a systemic condition that interferes in the health-disease process; Be pregnant or breastfeeding; Be smoker; Present allergy to chlorhexidine; To present partial removable prosthesis or fixed prosthesis / maladaptive restorations; No attendance for sample withdrawal, form filling and periodontal evaluations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To find significant differences in the use of chlorhexidine mouthrinse containing 0.3% tetrapalmitate (TPCHX) when compared to standard chlorhexidine (CHX) in the same period and frequency, with lower adverse effects and with a desirable therapeutic effect. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical evaluation of the primary outcome through: Change / decrease of bacterial plaque production and gingivitis in relation to grades of gingival index (GI); plaque index (PI); measurements of depth of probing and level of clinical insertion; and presence (+) or absence (-) for bleeding at probing using periodontal probe. | — |
Countries
Brazil
Contacts
Public ContactCarla Ribeiro Ferreira
Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara
Outcome results
None listed