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Ventilation Effects of Two-Phase Pressure compared to conventional ventilation in patients hospitalized in the ICU with community-acquired pneumonia

Effects of Ventilation Positive Biphasic Pressure compared to Protective Ventilatory Strategy in intensive care patients with Community-Acquired Pneumonia: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-62wfjg
Enrollment
Unknown
Registered
2018-11-01
Start date
2018-12-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial pneumonia

Interventions

1) Controlled Pressure Ventilation with the following settings: patient in 30-45 ° position, the airway pressure level will be adjusted to reach VT = 6 ml / kg, respiratory rate to reach pH> 7.30 and
PEEP level will be adjusted according to the PEEP-FiO2 table. VERSUS 2) Ventilation with Positive Biphasic Pressure: Patient at 30-45 ° position, High Pressure will be adjusted to reach VT = 6ml / k
Device
E01.370.386.700.660
C08.381.677

Sponsors

Hospital Pró Cardíaco
Lead Sponsor
Universidade Federal do Rio de Janeiro
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Signs and symptoms of pneumonia according to current guidelines; Age greater than 18 years;Being on invasive mechanical ventilation for up to 24 hours;Free and informed consent form obtained from the family

Exclusion criteria

Exclusion criteria: Transplantation (Organ and / or bone marrow);HIV positive;Immunosuppressive treatment (Corticosteroid);Tuberculosis; Hospitalization in other ICUs or emergency department in the last 14 days; Pregnancy; morbid obesity;severe liver disease;Pneumothorax;Clinical decision on palliative care;Estimated duration of mechanical ventilation less 48 hours;Neoplasms and neurological diseases

Design outcomes

Primary

MeasureTime frame
Increase in the number of free days of mechanical ventilation within a 28-day interval from entry into mechanical ventilation, as measured by daily visits while the patient is hospitalized.—

Secondary

MeasureTime frame
Increase survival by 28 days, measured every day through daily visits while the patient is hospitalized.;Increase or decrease of days of ICU stay measured through daily visits while the patient is hospitalized.;Increase or decrease of days of hospital stay measured by daily visits while the patient is hospitalized.;Increased or decreased inflammation markers, interleukins (IL) -8, IL-6, IL-1beta, C-reactive protein, pro-calcitonin, pro-endothelin observed on blood collection on days 1, 3, 7 and 28 through the Bradford method.;Increased or decreased epithelial injury markers sRAGE, SP-A, SP-D, Club Cell protein-16 in blood collection on days 1, 3, 7 and 28 through the Bradford method.—

Countries

Brazil

Contacts

Public ContactFelipe Saddy

Hospital Pró Cardíaco

fsaddy@gmail.com+55-021993336514

Outcome results

None listed

Source: REBEC (via WHO ICTRP)