Obesity, Overweight, Type 2 Diabetes Mellitus
Conditions
Interventions
Experimental group: 30 men and 30 women with normal weight or overweight / Obesity or overweight / obesity with Type 2 diabetes, will undergo a combined physical training program consisting of a 30-35
Other
G11.427.410.698.277
Sponsors
Faculdade de Educação Física da Universidade Estadual de Campinas
Faculdade de Ciências Médicas da Universidade Estadual de Campinas
Eligibility
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: Body mass index (BMI) between 18.5-34.9 kg / m²; insufficiently active; presence or absence of type 2 diabetes.
Exclusion criteria
Exclusion criteria: Disapproval on physical and cardiological examination; presence of certains disease(coronary artery disease, severe arterial hypertension, chronic obstructive pulmonary disease, limiting osteo-articular diseases) or other general or specific/severe complications of T2DM that may interfere with the results of the research or represent a risk factor to the physical training; Use of exogenous insulin, thiazolidinediones, beta-blockers, anticoagulants to not interfere in the physiological responses to tests or training.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcomes will be considered effective if an interaction between group and tpopo (any time measured compared to the pre-intervention moment) with p-value less than 0.05. Molecular characteristics of the subcutaneous fat of the waist region verified by the Real Time technique - Polymerase Chain Reaction (PCR) (fold change);The outcomes will be considered effective even if an interaction between group and tpope (any time measured compared to the pre-intervention moment) with a p-value less than 0.05 is observed. Activity in kilo Becquerel (kBq) and volume in cubic centimeters (cm³) of cervical / scapular brown adipose tissue evaluated by positron emission computed tomography (PET-CT) | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase in physical activity level, evaluated by the IPAQ and Baecke questionnaires (minutes per week) before and after 16 weeks of the experimental period;Improvement in cardiorespiratory fitness assessed by the maximal oxygen consumption test (VO2) by gas analysis (ml / min / kg) before and after 16 weeks of the experimental period;Improvement in quality of life assessed by the WHOQOL-BREF questionnaire (QVG) before and after 16 weeks of the experimental period;Improvement in lifestyle assessed by the "Fantastic" questionnaire (points) before and after 16 weeks of the experimental period;Maintenance of food behavior evaluated by Food Reminders (grams/day of carbohydrates - fat - protein and total kilocalories/day) before and after 16 weeks of the experimental period;Maximum and submaximal strength improvement (kilos) evaluated by the maximum repetition test and 12 maximum repetitions before and after 16 weeks of the experimental period;Anthropometry improve evaluated by weight (kilograms), height (cm), body mass index (BMI) (kg / m²), and waist circumference (cm) before and after 16 weeks of the experimental period;Improvement of body composition using plethysmograph and dual X-ray densitometry (DEXA) for analysis of fat-free mass and fat mass in kilograms (kg) and percentages (%) before and after 16 weeks of the experimental period;Improvement of lung function (total capacity and expired volume) assessed by spirometry before and after 16 weeks of the experimental period;Improvement of clinical biochemical blood markers lipid profile (total cholesterol, triglycerides, HDL, LDL, VLDL (Mg / dl), glucose (mg / dl), glycated hemoglobin (%), blood count (g / dl and mm³), insulin (ui / ml), peptide c (ng / dl), thyroid- TSH (IU / ml) using kits and techniques commercially available before and after 16 weeks of the experimental period;Insulin resistance decrease and insulin sensitivity increase using the index homeostasis model, QUICKI index, TYG index - glucose / tr | — |
Countries
Brazil
Contacts
Public ContactIvan Bonfante
Faculdade de Educação Física da Universidade Estadual de Campinas
Outcome results
None listed