The impact of green propolis on inflammation and cellular damage in overweight postmenopausal women

The evaluation of the effects of green propolis supplementation on low-grade chronic inflammation and oxidative stress in overweight and obese women in postmenopause

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-62m6v2w

Enrollment

Registered

2026-05-18

Start date

2025-11-10

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity Nutritional and Metabolic Diseases

Interventions

This is a randomized, double-blind, placebo-controlled clinical trial with two parallel intervention groups conducted over eight weeks to evaluate the effects of green propolis dry extract supplementa

Eligibility

Sex/Gender

Female

Age

45 Years to No maximum

Inclusion criteria

Inclusion criteria: Postmenopausal women, according to the guidelines of the United Kingdom's National Institute for Health and Care Excellence (2017); minimum age of 45 years; last menstrual period at least 12 months ago and no use of hormonal contraception; women without a uterus who present vasomotor symptoms characteristic of menopause

Exclusion criteria

Exclusion criteria: Women who abuse alcohol or drugs; those diagnosed with autoimmune diseases; those who have neoplasms (cancer)

Design outcomes

Primary

Measure	Time frame
It is expected to find a reduction in the levels of inflammatory markers especially tumor necrosis factor alpha interleukin six and C reactive protein as well as a reduction in oxidative stress measured by nitric oxide concentration these variables will be measured by enzyme linked immunosorbent assay with blood collected at two time points before the intervention and at the end of eight weeks of oral supplementation with green propolis extract or placebo	—

Measure

Time frame

It is expected to find a reduction in the levels of inflammatory markers especially tumor necrosis factor alpha interleukin six and C reactive protein as well as a reduction in oxidative stress measured by nitric oxide concentration these variables will be measured by enzyme linked immunosorbent assay with blood collected at two time points before the intervention and at the end of eight weeks of oral supplementation with green propolis extract or placebo

—

Secondary

Measure	Time frame
Improvement in participants body composition with reduction in body weight body mass index and waist circumference measured at the beginning and end of the eight weeks of intervention using a digital scale and standard anthropometric tape biochemical variables of lipid and glycemic profiles will also be assessed including total cholesterol low density lipoprotein cholesterol high density lipoprotein cholesterol triglycerides and fasting blood glucose by blood analysis	—

Measure

Time frame

Improvement in participants body composition with reduction in body weight body mass index and waist circumference measured at the beginning and end of the eight weeks of intervention using a digital scale and standard anthropometric tape biochemical variables of lipid and glycemic profiles will also be assessed including total cholesterol low density lipoprotein cholesterol high density lipoprotein cholesterol triglycerides and fasting blood glucose by blood analysis

—

Countries

Contacts

Public ContactCláudio Orsatti

Associação Prudentina de Educação e Cultura

orsatti@unoeste.br+55 (14) 36241109

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Jun 11, 2026