Alveolar Bone Loss
Conditions
Interventions
This is a 3-arm, double-blind, randomized clinical study. Sites requiring both inlay and onlay reconstruction were enrolled in the study. In Control Group (CG, n=8), an anorganic xenograft was used in
Sponsors
Centro de Pesquisas Odontológicas São Leopoldo Mandic SS
Centro de Pesquisas Odontológicas São Leopoldo Mandic SS
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients of both genders; partially edentulous for more than 1 year; with absence of two teeth at least and at most five at the posterior maxilla (unilateral or bilateral); requiring implants in the posterior maxillary region with no more than 4 mm of remaining alveolar ridge; with need for maxillary sinus floor augmentation combined with onlay vertical bone augmentation in one or both sides; all patients should have between 18 and 65 years of age, with adequate oral health
Exclusion criteria
Exclusion criteria: Patients with a history of neoplastic disease treated with radiotherapy or chemotherapy; pregnant or breastfeeding; receiving treatment or affected by an illness that could influence on bone homeostasis; sinus pathologies; smokers; alcoholics; drug addicts
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1. It's expected to find absence of differences in the percentage of bone regenerated level (vital mineralized tissue - VMT), verified by histomorphometric analysis, using a comparative statistical analysis, for both inlay and inlay augmentations;Discovered outcome 1. It was verified a lower percentage (statistically significant) of newly formed bone (vital mineralized tissue - VMT), for onlay augmentations, in the test group 2 (TG2), in comparison with control (CG) and test 1 (TG1) groups, by using the histomorphometric analysis. For inlay augmentations, no difference was observed between groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2. It is expected to verify absence of statistical differences in bone volume between groups, measured by cone beam computed tomography, performed before and 6 months after grafting;Discovered outcome 2. It was verified absence of bone volume differences between groups, measured by cone beam computed tomography, performed before and 6 months after grafting | — |
Countries
Brazil
Contacts
Public ContactAndré Pelegrine
Faculdade São Leopoldo Mandic
Outcome results
None listed