Chronic periodontitis. Diabetes type 2
Conditions
Interventions
For the study there will be selected
thirty patients with chronic periodontitis without systemic diseases in the test group 1,
thirty patients with chronic periodontitis associated with Type 2 diabe
Procedure/surgery
E06.721.189.350
Sponsors
Universidade de Brasília
Universidade Católica de Brasília
Eligibility
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Minimum of 15 teeth; least 30 percent of the sites with periodontal probing depth greater than or equal to 4 mm; at least two teeth with greater insertion loss than 3 mm; Age greater than or equal to 30 years. The control group will consist of individuals aged greater than or equal to 30 years; systemically healthy; Clinical and radiographic periodontal health; Minimum 20 teeth with less clinical probing depth or equal to 3 mm; lower insertion level at 3 mm; less than 10% of sites with bleeding on probing
Exclusion criteria
Exclusion criteria: Periodontal treatment in the last six months; Continued use of medications such as antibiotics, immunomodulators or anti-inflammatory drugs in the last three months; Systemic diseases that interfere with periodontal condition, except for diabetes for the test group (HIV, immune disorders, morbid obesity (BMI 40 kg / m2) or underweight (BMI less malnourished 18.5 kg / m2), etc.) ; Pregnant or lactating; smoking; Under age 30; Indigenous groups
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alteration of cell profiles evaluated in patients with type 2 diabetes and chronic periodontitis, by flow cytometry, from the finding of a change of at least 5% in the pre and post-intervention measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| Alteration of systemic mediators evaluated in patients with type 2 diabetes and chronic periodontitis, using the enzyme linked immunosorbent assay (ELISA), from the finding of a change of at least 5% in the pre and post intervention measurements of cytokines pro and anti-inflammatory.;Alteration of systemic mediators evaluated in patients with type 2 diabetes and chronic periodontitis, using the dotenzyme immunoassay technique (dot-ELISA), from the finding of a change of at least 5% in pre- and post-intervention measurements of immunoglobulins A , G and M.;Changing the microbiological profile evaluated in patients with type 2 diabetes and chronic periodontitis, using the polymerase chain reaction (PCR), from the finding of a change of at least 5% in pre measurements and post intervention of 8 main periodontopathogens. | — |
Countries
Brazil
Contacts
Public ContactPriscilla Naiff
Universidade de Brasília
Outcome results
None listed