Keratoconus, mutation, gene
Conditions
Interventions
Group or experimental case:
60 keratoconus patients (confirmed by Orbscan) aged 18 to 40 years old with no other ophthalmic disease or previous surgery or systemic diseases. 5 ml of blood will be co
Genetics
G05.365.795
Sponsors
Universidade Federal de Goias
Fundação Banco de Olhos
Eligibility
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Volunteers between 18-40 years of age with keratoconus; without keratoconus; no surgery or previous eye diseases; absence of systemic diseases; who accept sign the consent form and clarification
Exclusion criteria
Exclusion criteria: volunteers under the age of 18 years and above 40 years; who did not accept to sign the consent form and enlightenment; with diseases or previous eye surgery; systemic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It`s hoped the polymorphism of the gene VSX1, mir-184, DOCK9 in patients with keratoconus and not the phenotype expression in control patients;Observe VSX1 gene polymorphism, mir-184 and DOCK9 by qPCR technique for identifying DNA mutant alleles | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that the polymorphism VSX1 genes, miR-184, DOCK9 is expressed in at least 5% of the population with keratoconus and is statistically significant compared to controls | — |
Countries
Brazil
Contacts
Public ContactFrancisco Rodrigues
VER-exelencia em oftalmologia
Outcome results
None listed