Varicocele
Conditions
Interventions
40 men with varicocele will be evaluated as to the effect of the surgery of varicocele correction in sperm DNA fragmentation, sperm quality and hormonal parameters. There will be randomly allocated in
Procedure/surgery
Sponsors
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Faculdade de Medicina de Ribeirão Preto
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Men with varicocele in grades II and III; aged between 18 and 45; not having undergone previous varicocelectomy.
Exclusion criteria
Exclusion criteria: Smoking; excessive use of alcohol; drug abuse; genetic damage; prior varicocele correction surgery; testicular trauma; urogenital infections suspicion; cancer; endocrinopathies; treatments that may influence the testicular functions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in sperm DNA fragmentation rate, semen quality and hormonal parameters in men with varicocele who underwent or not to varicocelectomy, verified by comparative analysis before and after nine months of intervention. For the evaluation of outcomes will be used Halosperm G2® kit for the analysis of sperm DNA fragmentation rate, spermogram following the normal range indicated by the World Health Organization (2010) to assess the seminal quality, and serum levels of hormones FHS, LH, prolactin, SHBG and FAI for hormonal evaluation. A determination of whether there are differences between the parameters evaluated before and after nine months will be made, and from statistical analysis between groups, the changes are considered significant to achieve p <0.05. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected. | — |
Countries
Brazil
Contacts
Public ContactRosana;Rosana dos Reis;Reis
Faculdade de Medicina de Ribeirão Preto;Faculdade de Medicina de Ribeirão Preto
Outcome results
None listed