Chronic Periodontitis
Conditions
Interventions
Participants: 20 patients diagnosed with periodontitis in stage II or III and Grade A, according to the criteria established by the AAP and EFP, with at least two non-adjacent sites in two different q
Procedure/surgery
Other
E06.721.189.350
Sponsors
Faculdade de Odontologia de Araraquara - Universidade Estadual Paulista
Conselho Nacional de Pesquisa
Eligibility
Inclusion criteria
Inclusion criteria: Healthy; 30 years of age or more; presence of periodontitis, in stage II or III and Grade A, in at least 2 sites in 2 different quadrants, with Probing Pocket depth between 5 and 8 mm and active periodontal disease, verified by the presence of bleeding on probing; minimum 15 teeth present; availability for a period of 6 months
Exclusion criteria
Exclusion criteria: Presence of systemic diseases that contraindicate periodontal treatment, which require antibiotic prophylaxis or use of medications that could interfere with the evolution of periodontal disease and / or treatment outcome; history of gastroesophageal reflux, peptic ulcer, duodenal ulcer and gallstones; gestational or lactating women; smokers or ex-smokers who have stopped smoking for less than 5 years; have been using antimicrobials in the last six months; have been using steroid or non-steroidal anti-inflammatory drugs continuously for more than 7 days in the past 3 months; have received periodontal treatment in the last year; have less than 15 teeth present.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Attachment Level determined as the distance from the cemento-enamel junction to the base of the pocket / periodontal sulcus, calculated from the values of Probing pocket depth and Gingival Recession. This clinical parameter will be registered at the baseline, 30, 90 and 180 days after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Protein level of the cytokines IL-1alpha, IL-6, IL-10, TNF-alpha. Crevicular gingival fluid samples will be collected at the baseline, 3, 7 and 15 days after treatment. Samples will be analyzed by the ELISA test;Bacterial species: Subgingival biofilm samples will be collected at the baseline, 3, 7 and 15 days after treatment. Samples will be analyzed by the DNA-DNA hybridization checkerboard technique;Probing pocket depth determined as the distance from the gingival margin to the bottom of the pocket or periodontal sulcus in millimeters (mm). It will be measured with the aid of a North Carolina periodontal catheter (PUNC # 15, Hu-Friedy) at baseline, 30, 90 and 180 days after treatment.;Gingival recession determined as the distance from the cementum-enamel junction to the gingival margin, and will be measured with the aid of a North Carolina periodontal probe (PUNC # 15, Hu-Friedy) at baseline, 30, 90 and 180 days after treatment;Plaque index: with previously dry teeth, the absence or presence of plaque accumulation in all patients' teeth (Ainamo & Bay) will be recorded. It will be recorded at the baseline, 30, 90 and 180 days after treatment.;Marginal bleeding index: will be verified presence or absence of bleeding of the marginal gingiva after lightly traversing (with the North Carolina periodontal probe (PUNC # 15, Hu-Friedy)) the periodontal sulcus of all teeth. It will be recorded at the baseline, 30, 90 and 180 days after treatment.;Bleeding on probing; the presence of bleeding will be verified up to 15 seconds after the periodontal probing, with the aid of the North Carolina periodontal probe (PUNC # 15, Hu-Friedy). It will be recorded at the baseline, 30, 90 and 180 days after treatment. | — |
Countries
Brazil
Contacts
Public ContactCARLOS;Carlos ROSSA JR;Rossa Jr
Faculdade de Odontologia de Araraquara - Universidade Estadual Paulista ;Faculdade de Odontologia de Araraquara - Universidade Estadual Paulista
Outcome results
None listed