Ventilation
Conditions
Interventions
In the NIV group: 14 patients with COPD-IC coexistence will be evaluated and will receive, during constant load exercise, the application of non-invasive ventilation with IPAP of 8-12 and EPAP of 4-6.
Sponsors
Universidade Federal de São Carlos
Universidade Federal de São Carlos
Eligibility
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 50 years or more; diagnosis of coexisting COPD and HF; FEV1 to CVF ratio of 0.7; left ventricular ejection fraction less than 50%; New York Heart Association Functional Classification I-IV; optimized medical therapy
Exclusion criteria
Exclusion criteria: musculoskeletal disorders or neurological conditions that affect exercise capacity; deterioration of the clinical condition requiring hospitalization 3 months before the study; diagnosis of malignant disease; implantable pacemaker; myocardial infarction 3 months before the study; complex cardiac arrhythmias
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the acute effects of the bilevel during constant load exercise on ventilatory, cardiocirculatory mechanical responses, muscle and brain oxygenation, endothelial function and exercise tolerance in patients with COPD-IC. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is hoped that the bilevel can improve exercise intolerance in the face of COPD-IC, reduce ventilatory and circulatory mechanical changes, and also improve endothelial function and central and peripheral oxygen supply in these patients. | — |
Countries
Brazil
Contacts
Public ContactAudrey Borghi-Silva
Universidade Federal de São Carlos
Outcome results
None listed