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Cardiopulmonary rehabilitation with and without blood flow restriction during resistance training in heart failure

Exercise-based rehabilitation program with versus without blood flow restriction in individuals with heart failure with reduced ejection fraction

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-5y8k7d7
Enrollment
Unknown
Registered
2026-01-27
Start date
2024-01-01
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Interventions

This is a randomized controlled clinical trial with two arms open label with 1:1 allocation the desired number of participants is 52 with 26 in each group participants will be randomized using an elec

Sponsors

Universidade Católica de Brasília
Lead Sponsor
Universidade Católica de Brasília
Collaborator

Eligibility

Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients aged between 40 and 70 years; of both sexes; diagnosed with Heart Failure with Reduced Ejection Fraction (HFrEF) or Heart Failure with Preserved Ejection Fraction (HFpEF); classified as functional class II or III according to the New York Heart Association (NYHA); on stable optimized medical therapy; heart failure with ejection fraction equal to or less than 40%

Exclusion criteria

Exclusion criteria: Any relative or absolute contraindication to exercise; presence of pacemaker with fixed heart rate and heart rate limits below the target proposed for physical training; major cardiovascular events or procedures performed within two months prior to study inclusion

Design outcomes

Primary

MeasureTime frame
It is expected to evaluate the evolution of serum levels of B-type natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) before and after a training program with or without blood flow restriction, verified through standardized laboratory measurement, based on the observation of a significant reduction in mean values between baseline and after 12 weeks of intervention—

Secondary

MeasureTime frame
It is expected to generate new clusters of patients with heart failure capable of identifying good responders to cardiac rehabilitation methods, verified through lipidomic, metabolomic, microRNA analyses and flow-mediated dilation, based on the observation of specific phenotypic patterns that allow the development of personalized treatments in patients with severe heart failure—

Countries

Brazil

Contacts

Public ContactLuiz Sérgio de Carvalho

Universidade Católica de Brasília

luiz.carvalho@p.ucb.br+55 61 981783254

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 7, 2026