Melatonin
Conditions
Interventions
This is a prospective, placebo-controlled and randomized, triple-blind, intra-subject (i.e., subjects are their own control group) and cross-over (i.e., subjects perform all trials and experimental pr
or b) oral administration of a placebo tablet (i.e., without melatonin) produced with a similar vehicle solution and the same conditions (i.e., volume, shape, size and color)
applied 45 minutes before carrying out the physical exercise protocols. In view of the general objective, this research will be segmented into three experiments, each involving specific phy
G11.427.410.698.277
Sponsors
Universidade Federal de São Carlos - UFSCar
Universidade Estadual de Campinas - UNICAMP
Eligibility
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Men and women aged between 18 and 35; apparently healthy; physically independent; normotensive; non-obese (i.e., Body Mass Index greater than 30 kilograms per square meter and body fat percentage less than 20 percent; not tobacco or alcohol users; moderately active (i.e., greater than or equal to 150 minutes per week of physical activity ); engaged in regular physical training programs.
Exclusion criteria
Exclusion criteria: Subjects who self-report cardiovascular, metabolic diseases, sleep and neuromuscular disorders and/or musculoskeletal injuries; continuous use of dermatological medications and antipyretics and diuretics; have used ergogenic substances (e.g., anabolic androgenic steroids) in the last six months prior to the start of research; skin folds in the regions of interest (front of the thigh and arm) greater than 20 millimeters.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find effects of acute administration of melatonin on physiological parameters and physical performance during and after running under different conditions in active and healthy individuals. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to find an ergogenic effect of exogenous melatonin on physical performance, exemplified by longer exhaustion time and lower respiratory quotient at ventilatory threshold 2, assessed by spirometry examination, during incremental effort (TInc).;It is expected to find an ergogenic effect of exogenous melatonin on physical performance, exemplified by a greater time limit and lower respiratory quotient during a time limit test (TLim) performed at an intensity corresponding to ? 90% of maximum aerobic capacity, assessed by spirometry examination, not being the same reported for other physiological parameters.;It is expected to find an ergogenic effect of exogenous melatonin on physical performance, exemplified by the improvement in hemodynamic, inflammatory, psychophysiological, metabolic and tissue damage parameters during a fixed load test (TCFixa) performed at an intensity corresponding to ? 90% of maximum aerobic capacity and time determined, evaluated by spirometry examination, heart rate monitoring, near infrared spectroscopy and blood analysis. | — |
Countries
Brazil
Contacts
Public ContactJean de Souza
Universidade Federal de São Carlos - UFSCar
Outcome results
None listed