Glaucoma
Conditions
Interventions
Patients were selected from FUBOG (Fundação Banco de Olhos de Goiás) and CEROF-UFG (Centro de Referência em Oftalmologia - Universidade Federal de Goiás), using prostagandin analogues in the preopera
D10.251.355.255.550.775
Sponsors
Universidade Federal de Goiás
Fundação Banco de Olhos de Goiás
Eligibility
Inclusion criteria
Inclusion criteria: Pacients of all ages with Primary Glaucoma; Primary Open Angle Glaucoma; Primary Narrow Angle Glaucoma; Normal Pressure Glaucoma; Pigmentary Glaucoma; Pseudoexfoliative Glaucoma; visual field changes; typical defect compatible with glaucomatous lesion and/or typical anatomical involvement of the optic disc or nerve fiber layer of the retina (such as Hoyt´s sign, cupping ratio greater than 0.7, localized neural rhyme defect, or cupping asymmetry); indication of trabeculectomy at medical discretion (example: uncontrolled intraocular pressure or impossibility of using medication due to allergy or financial conditions); need to reduce the intraocular pressure by at least 20% in relation to the baseline in the postoperative period for inclusion; intraocular pressure above the traget established for the case and with medication
Exclusion criteria
Exclusion criteria: Any pathology that could interfere with the results of the tests; low quality of exams; any previous macular pathology; use of diamox; advanced glaucoma with maximal therapy; advanced glaucoma with impaired fixation; any surgical complications including hypotonia in any evaluation; performing combined cataract and glaucoma surgery; need for surgical intervention; reintrodution of therapy with prostaglandin analogues
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected Outcome 1: Evaluate changes in macular thickness in both groups, in use and not prostaglandin analogue eye drops, after surgery to reduce intraocular pressure during postoperative follow-up using Optical Coherence Tomography by means of delta variations, delta percentages, correlations of macular parameters with intraocular pressure at different times. It is expected do observe that in delta, delta percentages and in correlations between the groups there is no p value with statistical significance between them.;Outcome found 1: Evaluate changes in macular thickness were in both groups, in use and not prostaglandin analogue eye drops, after surgery to reduce intraocular pressure during postoperative follow-up using Optical Coherence Tomography by means of delta variations, delta percentages, correlations of macular parameters with intraocular pressure at different times. It was found in delta and delta percentage p values with statistical significance ( p= 0,013 and p= 0,011, respectivaly) in the upper macular thickness parameter between groups. e of p that the use of prostaglandin analogues before surgery did not demonstrate clinical significance or impact on postoperative macular thicknesses. The statistically difference found between the groups was very small, within the very coefficient variation of the Optical Coherence Tomography device. In the correlation test, no differences were found between the groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected | — |
Countries
Brazil
Contacts
Public ContactSula Britto
Centro de Referência em Oftalmologia
Outcome results
None listed