Migraine
Conditions
Interventions
A total of 76 participants with headache were divided into two equal groups: 38 with migraine and 38 with tension-type headache (control). Both groups were submitted to watermelon ingestion, in a stan
G07.203.300.456
Sponsors
Federal University of Piauí
Federal University of Piauí
Eligibility
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Medicine student; Age between 18 and 50 years old; Brazilian nationality; Agree to undergo anamnesis, watermelon ingestion and blood collections; Diagnosis of migraine or other primary headache according to ICHD-3 criteria; and Be headache-free for at least 48 hours before ingesting the watermelon.
Exclusion criteria
Exclusion criteria: Headache frequency greater than or equal to 15 days per month; Women with headache only during the menstrual period; Association of migraine with other primary headache; In use of migraine prophylactics; Diagnosis of secondary headaches or unclassified headache; History of citrulline amino acid allergy; Consumption of watermelon or other sources of citrulline in the last 7 days; Intake of food supplement rich in citrulline; Associated diseases that would be compromised by ingestion of watermelon; Use of medications that compromise watermelon intake Diabetic patients; and Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Headache triggering was expected to be found only in patients with migraine, using watermelon ingestion in both groups.;Outcome found 1: Headache triggering was observed in 23.7% of patients with migraine and in none of patients with tension-type headache. | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome found 2: An increase in serum nitrite levels was observed after watermelon ingestion (23.37 mcg/mL versus 27.92 mgc/dL).;Expected outcome 2: In patients with migraine, it was expected to find an increase in serum nitrite, using blood measurements and comparing the two blood samples. | — |
Countries
Brazil
Contacts
Public ContactGabriela;Natália Bezerra;Araújo
Federal University of Piauí;Federal University of Piauí
Outcome results
None listed