Von Willebrand's disease
Conditions
Interventions
20 participants diagnosed with IHD and AUB were enrolled in a prospective clinical study to compare volume of menstrual bleeding and quality of life before and after LNG-IUD placement. We used a picto
Device
Sponsors
Faculdade de Medicina-Universidade Federal de Minas Gerais
Faculdade de Medicina-Universidade Federal de Minas Gerais
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Participants were women previously diagnosed with inherited coagulopathies presenting excessive menstrual bleeding
Exclusion criteria
Exclusion criteria: Myomatosis; use of anticoagulants; uterine malformations; contraindications to the use of levonorgestrel device
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: To evaluate the efficiency of LNG-IUD use in controlling increased menstrual bleeding in patients with DHH verified by pictogram, amenorrhea rate, serum iron and ferritin levels, improvement of quality of life. ;Outcome found 1: We found that LNG-IUD proved to be a safe and effective method for use in patients with DHH, with satisfactory results in reducing bleeding and improving quality of life.;Expected outcome 2: To evaluate the reduction in uterine bleeding volume using the pictogram, comparing the bleeding volume of these patients before and 3 and 6 months after device insertion.;Outcome found 2: After 6 months, there was a significant reduction in menstrual bleeding volume, with a reduction in the average pictogram score from 407.0 to 8.3 (p menor que 0.001).;Expected outcome 3: To evaluate the proportion of these patients who progressed to amenorrhea through medical interview and physical examination at 3 and 6 months after the intervention.;Outcome found 3: After 6 months, there was a significant reduction in menstrual bleeding volume, with a reduction in the average pictogram score from 407.0 to 8.3 (p menor que 0.001) with amenorrhea in 75% of cases.;Expected outcome 4: To assess whether reduction in uterine bleeding altered serum hemoglobin, serum iron and serum ferritin levels before and 6 months after insertion of the LNG-IUD. This outcome was assessed by serum hemoglobin, iron and ferritin levels before the intervention and at 3 months and 6 months after the intervention.;Outcome found 4: There was no statistical difference in serum hemoglobin and ferritin values, but there was a significant increase in serum iron values (mean 73.7 pretreatment and 101.3 after 6 months; p igual a 0.003).;Expected outcome 5: Evaluate the improvement of patients' quality of life after device insertion by applying the SF-36 questionnaire, which was applied before insertion and 6 months after.;Outcome found 5: Regarding the assessment of qualit | — |
Secondary
| Measure | Time frame |
|---|---|
| No Secondary Outcomes Expected | — |
Countries
Brazil
Contacts
Public ContactAna Lunardi
Faculdade de Medicina-Universidade Federal de Minas Gerais
Outcome results
None listed