Analgesic effect and muscle activity of Electrical Cortical Stimulation assited by Peripheral Electrical Stimulation in healthy volunteers

Effects of Electrical Cortical Stimulation assisted by Peripheral Electrical Stimulation (priming) on ??activation of descending pain inhibitory pathway and electrical muscle activity in healthy volunteers

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

REBEC

Registry ID

RBR-5vwfqyx

Enrollment

Unknown

Registered

2024-03-18

Start date

2023-11-27

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Interventions

This is a clinical trial, randomized, crossover, double-blind, and sham-controlled study. Participants will be randomly assigned to four groups: (1) Real peripheral electrical stimulation-PES (priming

(2) Sham PES (priming), followed by real tDCS-a

(3) Real cathodal tDCS (priming), followed by real tDCS-a

(4) Sham cathodal tDCS (priming), followed by real tDCS-a. The PES will be applied before tDCS, using a rectangular, bifasic, asymmetric current equipment (Neurodyn III Ibramed, Brazil) with two self-

E02.331.800

Eligibility

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Individuals of both sexes; aged 18 to 35 years; with no history of illnesses or previous surgeries and no complaints of pain (musculoskeletal or visceral)

Exclusion criteria

Exclusion criteria: Chronic pain; concomitant medication that may affect cognitive performance; pregnancy or possible history of pregnancy; drug or alcohol abuse or dependence; recent head injury (within the last 3 months); history of seizure or stroke; neurological; psychiatric diseases and rheumatologic

Design outcomes

Primary

Measure	Time frame
Activation of the pain inhibitory pathway, assessed by Conditioned Pain Modulation Test, during the first 30s.	—

Secondary

Measure	Time frame
Activation of the pain inhibitory pathway, assessed by Conditioned Pain Modulation Test, during the first 90s ;Activation of the pain inhibitory pathway, assessed by Conditioned Pain Modulation Test, post-60s	—

Countries

Brazil

Contacts

Public ContactRaquel Jacob

Universidade Federal do Delta do Parnaiba-UFDPar

raquelrocha@ufpi.edu.br+55 (86) 9 8108-6513

Outcome results

None listed

Source: REBEC (via WHO ICTRP)