Type 2 diabetes, obesity, bariatric surgery.
Conditions
Interventions
Controlled study: one experimental group and two control groups. Experimental group: 10 obese grade I and II patients with type 2 diabetes who underwent biliopancreatic diversion surgery. Evaluated pr
Procedure/surgery
Sponsors
Universidade Estadual de Campinas
Universidade Estadual de Campinas
Eligibility
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age between 30 and 60 years, type 2 diabetic patients without medication for diabetes or who are not making use for at least 3 months; weight variation of less than 5% in the last three months; ability to understand the study procedures and voluntarily agree to participate in the study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: Age under 30 and over 60, patients with type 2 diabetes using insulin, type 2 diabetics with poorly controlled diabetes (glycated hemoglobin A1c greater than 8.5%), BMI less than 18.5 kg / m²; history of liver disease such as cirrhosis or chronic active hepatitis; changing functions renal function (creatinine greater than 1.4 mg / dl in women and greater than 1.5 mg / dl in men) and hepatic ALT and / or AST 3 times above normal; recent history of malignancy (less than 5 years), use of injectable or oral steroids for more than 14 consecutive days in the past 3 months, or with some drug side effects on glucose metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the incretin effect evaluated by isoglycemic clamp technique in healthy, obese subjects with normal glucose tolerance and type 2 diabetic obese.;No statistical difference was found between the incretin effect of different groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the "incretin profile" evolution by isoglycemic clamp technique in the group of obese diabetic patients 1 and 12 months after surgery by the technique of biliopancreatic diversion.;Improvement on incretin effect one year after biliopancreatic diversion surgery assessed by isoglycemic clamp test. | — |
Countries
Brazil
Contacts
Public ContactBruno Geloneze
Universidade Estadual de Campinas
Outcome results
None listed