Evaluation of the use of local hemostatic agents in patients on oral anticoagulants undergoing mandibular molar extraction

Evaluation of the use of local hemostatic agents in oral anticoagulated patients on the control of bleeding, pain, trismus, scar repair and quality of life in lower molar removal surgeries

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-5vcvk5n

Enrollment

Registered

2026-07-15

Start date

2025-01-05

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Hemorrhage Hemorrhage

Interventions

During the pre-surgical consultation, data regarding sex, age, general health status, complete blood count (CBC), platelet count, International Normalized Ratio (INR), and glycated hemoglobin will be

oxidized regenerated cellulose (Equitamp®) immediately after tooth extraction (G2)

or tranexamic acid (Transamin®) immediately after tooth extraction (G3). In the postoperative period, all volunteers across all groups will receive supportive medication. Postoperative instructions wi

s postoperative periods, such as

Eligibility

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Individuals of both sexes; aged 18 to 75; with controlled or uncontrolled mild systemic disease who are taking warfarin and have an International Normalized Ratio between 2.0 and 4.5; and who require the extraction of permanent mandibular molars without periapical lesions

Exclusion criteria

Exclusion criteria: Volunteers meeting at least one of the following criteria will be excluded: smokers; pregnant or breastfeeding women; users of medications that might interact with the drugs used in this study; signs of any preoperative inflammatory or infectious condition; neurological disorders/disabilities; hepatic dysfunction; thrombocytopenia; immunosuppression; radiotherapy; or chemotherapy within the past year; bisphosphonate and antiresorptive therapy; and patients with hypersensitivity or allergic reactions to the local anesthetic

Design outcomes

Primary

Measure	Time frame
An improvement in bleeding control/hemostasis is expected after lower molar extractions	—

Secondary

Measure	Time frame
An improvement is expected in clinical parameters related to inflammatory events (pain and trismus); evaluation of scar repair and the impact on patients' quality of life during the postoperative period	—

Countries

Contacts

Public ContactEdson Cetira Filho

Centro Universitário Christus - UNICHRISTUS

edson.cetira@hotmail.com+55(85)997219653

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026