Mild Cognitive impairment, late onset Alzheimer disease.
Conditions
Interventions
Selected subjects (N=80) will be submitted to a supervised physical exercise program. The program is based on treadmill walking, twice a week, for 24 weeks. Subjects are submitted to a effort test bef
Behavioural
Other
E02.779.483
G11.427.590.530.698.277
Sponsors
Universidade de São Paulo
Universidade de São Paulo
Eligibility
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with mild cognitive impairment
Exclusion criteria
Exclusion criteria: Individuals with cognitive decline of sufficient intensity for the diagnosis of dementia will be excluded, as well as individuals with psychiatric disorders in activity (not in remission now). Other exclusion criteria include clinical illness or physical disability that prevents the achievement of aerobic exercise, auditory and visual impair cognitive assessment, scores on the questionnaire functionality Pfeffer greater than four and illiteracy. Here we characterize illiteracy to less than one year of formal education and inability to read the phrase "Close your Eyes" mini mental state examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome: changes in brain metabolism at rest state, in important regions for cognition. The results will be compared by paired t test, using values generated by positron emission tomography. The significance level considered was P <0.05. ;Found outcome: In the analysis of the first 40 subjects, we found reduction in the resting metabolism of the rostral posterior cingulate cortex, bilaterally. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome: Improvement of cognitive measures obtained by neuropsychological assessment. Neuropsychological assessments are conducted by trained neuropsychologists. The results will be compared with the paired t-test and significance values stipulated in p <0.05.;Found outcome: In the analysis of the first 40 subjects, we found improvements on scales that measure: 1) Global cognition - ADAS-cog; 2) Visual memory - Wechsler Memory Scale - revised (WMS-R); 3) Visuospatial function - copy of the Rey-Osterrieth complex figure. | — |
Countries
Brazil
Contacts
Public ContactFábio Porto
Universidade de São Paulo
Outcome results
None listed