Hypertension
Conditions
Interventions
Patients will be randomly allocated and double-blind in the control group (n = 53) or in the treatment group (n = 53). The treatment group will receive tincture prepared with Justicia pectoralis leave
32339
59046
Sponsors
Faculdade de Medicina de Ribeirão Preto -USP
Faculdade de Medicina de Ribeirão Preto -USP
Eligibility
Age
12 Years to 80 Years
Inclusion criteria
Inclusion criteria: Men, non-pregnant women, older than 12 years old and less than or equal to 80 years old, diagnosed with Hypertension and on at least monotherapy regimen for this disease.
Exclusion criteria
Exclusion criteria: Pregnant or lactating women; hypertension due to secondary cause; coagulopathies; individuals who use any other herbal medicine during the study; individuals who have a serious adverse reaction to the medication, individuals who request their withdrawal from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome of the study will be the decrease of at least 10 mm Hg in the mean systolic blood pressure of 24 hours verified by ambulatory blood pressure monitoring in the treatment group and 60 days after the intervention. Data collected before the start of treatment and 60 days after. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will be: decreased arterial stiffness in the treatment group verified by decrease in pulse wave velocity in relation to the placebo group after 60 days of intervention. Procedure performed one day before the start of treatment and 60 days after treatment; increase in nitrite and nitrosothio levels in relation to baseline in the treatment group quantified in plasma after 60 days of intervention. Dosage performed one day before the start of treatment and 60 days after treatment. | — |
Countries
Brazil
Contacts
Public ContactLucas Chaves
Outcome results
None listed