Arginine
Conditions
Interventions
Oral ibuprofen (400 mg) was administered to a group of 30 volunteers in the preoperative period of endodontic instrumentation in asymptomatic teeth, ibuprofen with arginine (400 mg) orally for a group
Drug
Sponsors
Universidade Estadual de Ponta Grossa
Centro de Ensino Superior dos Campos Gerais
Eligibility
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Men or women between 20 and 59 years of age in good health; Satisfy ASA I or II medical history according to the American Society of Anesthesiologists; Need for endodontic therapy in uni or multi-root teeth, asymptomatic with necrotic pulp; Volunteers who can provide informed consent.
Exclusion criteria
Exclusion criteria: Men or women under 20 years of age; Pregnant or lactating women; History of allergy or hypersensitivity to ibuprofen, arginine or local anesthetics; Need for antibiotic prophylaxis; Gastrointestinal disorders, esophageal reflux; Active asthma; Decreased hepatic function; Bleeding disorders; Decompensated diabetes mellitus; Ingestion of analgesics and anti-inflammatories in the last 12 hours (as it may exert a therapeutic effect at the time of the study); Intake of alcoholic beverage in the last 24 hours;Individuals classified as class III to V according to the American Society of Anesthesiologists; Individuals unable to provide informed consent.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The use of the drugs is expected to interfere positively in the quality of life and decrease of the anxiety of the volunteers. Quality of life will be measured using the OHIP-14 questionnaire and the anxiety will be measured using the IDATE-T and IDATE-E questionnaires. | — |
Primary
| Measure | Time frame |
|---|---|
| It is expected that there is a significant difference between the use of ibuprofen with arginine compared to conventional ibuprofen and placebo in the control of pain after endodontic instrumentation. Verified through the use of numeric pain scale (ENSR). | — |
Countries
Brazil
Contacts
Public ContactAmanda Fischborn
Universidade Estadual de Ponta Grossa
Outcome results
None listed