Kidney Neoplasms
Conditions
Interventions
This is a prospective, randomized, controlled, two-arm, double-blind clinical trial. A total of 78 eligible adult participants undergoing elective minimally invasive partial nephrectomy will be random
Sponsors
AC Camargo Cancer Center
AC Camargo Cancer Center
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients classified as American Society of Anesthesiologists (ASA) physical status I–III undergoing elective laparoscopic partial nephrectomy at the AC Camargo Cancer Center hospital complex
Exclusion criteria
Exclusion criteria: Obese patients (Body Mass Index > 30); patients with ASA physical status > III; those with contraindications to spinal anesthesia or quadratus lumborum block; patients with cognitive impairment precluding reliable assessment using the visual analog scale for pain; patients who develop severe clinical or surgical complications; patients with allergy to morphine or ropivacaine; and patients who refuse to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to compare pain scores at rest during the first 24 hours of the postoperative period in patients undergoing laparoscopic partial nephrectomy according to the analgesic technique used. The outcome will be assessed using the visual analog scale for pain at rest, applied at predefined time points throughout the first 24 hours after surgery. Absolute visual analog scale scores and changes over time will be compared between groups to identify clinically relevant differences in postoperative pain intensity. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to compare total opioid consumption between groups during the intraoperative period and the first 24 hours of the postoperative period. The outcome will be assessed by recording the total dose of opioids administered intravenously during surgery and the cumulative dose of morphine administered as rescue analgesia during the first 24 hours after surgery. Total opioid consumption will be compared between groups and expressed in milligram morphine equivalents.;It is expected to compare the incidence of adverse effects related to opioid use and analgesic techniques between patient groups. The outcome will be assessed through systematic clinical evaluation and recording of adverse events during the first 24 hours of the postoperative period. The frequency of events such as nausea, vomiting, pruritus, urinary retention, and respiratory depression will be analyzed and expressed as absolute numbers and percentages for each group.;It is expected to compare intraoperative vasopressor consumption between the study groups. The outcome will be assessed by recording the total doses of vasopressors administered intravenously during the surgical procedure. Cumulative vasopressor doses, expressed in or milligrams, will be compared between groups. | — |
Countries
Brazil
Contacts
Public ContactMatheus Vieira
AC Camargo Cancer Center
Outcome results
None listed