Periodontitis
Conditions
Interventions
This is a cross-sectional observational clinical study. The 45 participants will be recruited, of which 15 (Group P) will be diagnosed with grade C periodontitis
15 (DS Group) will have Down Syndrome (DS) and a diagnosis of Periodontitis, probing depth (PD) 4 mm and 15 (Control Group-C) will have neither DS nor periodontitis. Gingival crevicular fluid will be
Sponsors
Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho
Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho
Eligibility
Age
19 Years to 35 Years
Inclusion criteria
Inclusion criteria: Forty-five individuals will be recruited and allocated to one of three study groups, according to the inclusion criteria: group control (C): fifteen with systemically healthy individuals, without Down syndrome (DS) and who qualify in the following definition of periodontal and gingival health: no loss of clinical attachment, with probing depth of up to 3 mm, bleeding in less than 10% of sites, no radiographic bone loss and age between 19 and 35 years. Group P: fifteen systemically healthy individuals without DS; diagnosed with grade C, stage III or IV periodontitis and aged between 19 and 35 years. DS group: fifteen systemically healthy individuals, diagnosed with DS and periodontitis; as a manifestation of systemic diseases and aged between 19 and 35 years
Exclusion criteria
Exclusion criteria: Exclusion criteria will be: current or past smoking habit; pregnancy or breastfeeding; use of antibiotic or anti-inflammatory medication in the 6-month period prior to the study; previous periodontal treatment within 6 months before sample collection; diabetes or other systemic diseases that affect the immuno-inflammatory process
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparative analysis of the immuno-inflammatory profile of patients with periodontitis with and without Down Syndrome and with those of individuals without periodontal disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| Analyze the correlation of the analyzed biomarkers with the degree of attachment loss and periodontal disease. | — |
Countries
Brazil
Contacts
Public ContactLetícia Theodoro
Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho
Outcome results
None listed