Coronavirus Infections
Conditions
Interventions
Control group: saliva, blood and naso / oropharynx (swab) samples will be collected from 66 participants at different times after the onset of symptoms: T0 (3 to 8 days)
T1 (10 to 15 days) and T2 (17 to 22 days). Saliva will be collected at times T0, T1 and T2, blood at times T0 and T2 and the swab at times T0 and T2. A sample of unstimulated saliva will be collected
T1 (10 to 15 days) and T2 (17 to 22 days). Saliva will be collected at times T0, T1 and T2, blood at times T0 and T2 and the swab at times T1 and T2. A sample of unstimulated saliva will be collected
G07.203.650.250.800
E06.761.726.794
E01.370.225.998.110
Sponsors
Instituto Federal do Paraná
Instituto Federal do Paraná
Eligibility
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Case group: adult adults; 20 to 45 years; the city of Londrina; without comorbidities; non-smoking; of both sexes; with symptoms for CODIV-19; assisted at the Sabará-Londrina Emergency Care Unit. Control group: adult adults; 20 to 45 years; the city of Londrina; without comorbidities; non-smoking; of both sexes; no symptoms for CODIV-19.
Exclusion criteria
Exclusion criteria: Case group: volunteers who present comorbidities during the execution of the research; who start to use medication for continuous use that interferes with the quantity and quality of saliva; who in the course of the research are hospitalized for the treatment of the disease or give up participating in the research. Control group: volunteers who present comorbidities during the execution of the research; who start to use medications for continuous use that interfere in the quantity and quality of saliva; and that in the course of the research they are tested positive for COVID-19 or who quit participating of the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in the screening capacity of COVID-19, assessed by the identification of at least one saliva chemical or protein biomarker. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of SARS-CoV-2 viral load, assessed by polymerase chain reaction, by 50% after 30 minutes of tooth brushing. | — |
Countries
Brazil
Contacts
Public ContactMarcelo Poleti
Outcome results
None listed