Lung Diseases
Conditions
Interventions
Control group: 28 patients scheduled to undergo lower limb bypass surgery submitted to conventional mechanical ventilation (tidal volume of 9 to 10 ml / kg of predicted body weight and PEEP between 3
Procedure/surgery
Sponsors
Hospital de Clinicas de Porto Alegre
Hospital de Clinicas de Porto Alegre
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult ASA II to IV patients; older than 18 years; scheduled to undergo arterial bypass surgery in the lower limbs.
Exclusion criteria
Exclusion criteria: Patients with a body mass index above 40 kg / m2; submitted to emergency surgery; with a history of pulmonary surgery; persistent hemodynamic instability in the preoperative period; history of asthma or chronic use of corticosteroids; or patients with a history of neuromuscular disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the effects of mechanical ventilation with a protective strategy (treatment group - low tidal volume and high PEEP) in comparison to conventional mechanical ventilation (control group - high tidal volume and reduced PEEP) on the incidence of pulmonary complications (primary composite endpoint: insufficiency pulmonary infiltrates, pleural effusions, bronchospasm, cardiopulmonary edema, acute respiratory distress syndrome (ARDS)) in the perioperative period of patients undergoing coronary artery bypass graft surgery (CABG). Measures performed by clinical, laboratory or radiological means. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the effects of mechanical ventilation with a protective strategy (treatment group - low tidal volume and high PEEP) compared to conventional mechanical ventilation (control group - high tidal volume and reduced PEEP) on the incidence of cardiovascular complications (secondary outcome composed of events coronary syndromes, non-fatal infarction and / or cardiogenic shock) in the perioperative period of patients submitted to lower limb bypass surgery. Measures performed by clinical or laboratory means.;Evaluate the effects of mechanical ventilation with a protective strategy (treatment group - low tidal volume and high PEEP) compared to conventional mechanical ventilation (control group - high tidal volume and reduced PEEP) on the incidence of hemodynamic complications (secondary outcome consisting of shock distributive or persistent hypotension requiring the use of vasoactive drugs) in the perioperative period of patients submitted to lower limb bypass surgery. Measures performed through clinical or laboratory means.;Evaluate the effects of mechanical ventilation with a protective strategy (treatment group - low tidal volume and high PEEP) compared to conventional mechanical ventilation (control group - high tidal volume and reduced PEEP) on pulmonary and gasometric parameters in the perioperative period of patients undergoing lower limb bypass surgery. Measures performed through laboratory means. | — |
Countries
Brazil
Contacts
Public ContactAndre Schmidt
Hospital de Clinicas de Porto Alegre
Outcome results
None listed