Cerebral versus muscles adaptations promoted by two respiratory training programs in endurance–trained individuals

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-5rysw9w

Enrollment

Registered

2026-02-10

Start date

2024-06-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory muscles

Interventions

A parallel-group randomized controlled trial is conducted with 20 participants (14 men, 6 women), stratified by sex, using a 1:1 allocation ratio to compare two respiratory muscle training modalities

Eligibility

Age

19 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age 19 to 45 years; body mass index less than 25; absence of chronic disease or musculoskeletal injuries within the previous three months prior to enrollment; engagement in regular endurance training (at least 3 sessions per week, 30min or more per session) for at least six months prior to enrollment

Exclusion criteria

Exclusion criteria: Use of any legal or illegal performance–enhancing substances; acute infections or inflammatory processes within two weeks prior to initial testing

Design outcomes

Primary

Measure	Time frame
Expected outcome: medium to large effect size (Cohen's f = 0.30) of changes in tissue saturation index, assessed by near-infrared spectroscopy, in the prefrontal cortex, locomotor muscles, or respiratory muscles during high-intensity constant-load cycling induced by respiratory muscle training;Observed outcome: Prefrontal cortex tissue saturation index remains stable at approximately 68–72% during high-intensity constant-load cycling. Intercostal muscles show a decrease in tissue saturation index from ~68% at baseline to ~58% at exhaustion. Locomotor muscles show an increase in tissue saturation index of ~3–4% post-training across time points regardless of group, suggesting improved tissue oxygenation following respiratory muscle training. No significant differences are observed between training modalities	—

Measure

Time frame

Expected outcome: medium to large effect size (Cohen's f = 0.30) of changes in tissue saturation index, assessed by near-infrared spectroscopy, in the prefrontal cortex, locomotor muscles, or respiratory muscles during high-intensity constant-load cycling induced by respiratory muscle training;Observed outcome: Prefrontal cortex tissue saturation index remains stable at approximately 68–72% during high-intensity constant-load cycling. Intercostal muscles show a decrease in tissue saturation index from ~68% at baseline to ~58% at exhaustion. Locomotor muscles show an increase in tissue saturation index of ~3–4% post-training across time points regardless of group, suggesting improved tissue oxygenation following respiratory muscle training. No significant differences are observed between training modalities

—

Secondary

Measure	Time frame
There is no secondary outcome expected	—

Countries

Chile

Contacts

Public ContactDaniel Ramos–Lopez

Pontificia Universidad Católica do Chile

dmramos@uc.cl+56 (9) 8262 6805

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Mar 14, 2026