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Effect of Citrulline Malate on sports performance and physiological responses in adolescent competitive swimmers

Effect of acute citrulline-malate supplementation and influence of polymorphisms in the ACTN3, ACE and NOS3 genes on the performance and recovery of swimming athletes: a randomized, triple-blind, placebo-controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-5rx7jqr
Enrollment
20
Registered
2026-07-01
Start date
2026-03-02
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Athletic Performance

Interventions

This is a randomized, triple-blind, placebo-controlled, crossover clinical trial with a target sample of 20 competitive adolescent swimmers from Pelotas, RS, Brazil. Participants will receive, in a ra

Sponsors

Faculdade de Nutrição da Universidade Federal de Pelotas
Lead Sponsor
Universidade Federal de Pelotas
Collaborator

Eligibility

Age
10 Years to 19 Years

Inclusion criteria

Inclusion criteria: Adolescent; competitive swimmers; aged 10 to 19 years; of both sexes; regularly engaged in swimming training and participating in regional, state, or national competitions; agreement to participate in the study and signature of the informed consent form by the legal guardian and assent by the adolescent when applicable

Exclusion criteria

Exclusion criteria: Musculoskeletal injury or clinical condition that prevents the performance of the physical tests; use of medications or supplements that may interfere with performance or physiological or biochemical responses; failure to comply with the study instructions; absence from any study stage

Design outcomes

Primary

MeasureTime frame
Total time to complete the 50 m freestyle swimming test, measured after acute supplementation with citrulline malate or placebo in each crossover condition;Total time to complete the 100 m freestyle swimming test, measured during the physical testing session after acute supplementation with citrulline malate or placebo in each crossover condition;Total time to complete the 200 m freestyle swimming test, measured during the physical testing session after acute supplementation with citrulline malate or placebo in each crossover condition

Secondary

MeasureTime frame
Evaluation of IL-1, IL-6, and IL-10 gene expression, measured in post-exercise blood samples collected after the physical testing session following acute supplementation with citrulline malate or placebo in each crossover condition;Evaluation of TNF-a gene expression, measured in post-exercise blood samples collected after the physical testing session following acute supplementation with citrulline malate or placebo in each crossover condition;Evaluation of heart rate, measured before intervention, before the physical tests, and immediately, 1 minute, 3 minutes, 5 minutes, and 10 minutes after each swimming test during the physical testing session following acute supplementation with citrulline malate or placebo in each crossover condition;Evaluation of blood pressure, measured before intervention, before the physical tests, and after the 200 m freestyle swimming test during the physical testing session following acute supplementation with citrulline malate or placebo in each crossover condition;Evaluation of handgrip strength, measured by hand dynamometry during the physical testing session following acute supplementation with citrulline malate or placebo in each crossover condition;Evaluation of rating of perceived exertion, measured by the Borg scale after each swimming test (50 m, 100 m, and 200 m) during the physical testing session following acute supplementation with citrulline malate or placebo in each crossover condition;Expected evaluation of thiobarbituric acid reactive substances levels (TBARS), measured in post-exercise blood samples collected after the physical testing session following acute supplementation with citrulline malate or placebo in each crossover condition;Evaluation of the 50 m split time during the 100 m freestyle swimming test, measured by the time recorded at the first 50 m segment during the physical testing session after acute supplementation with citrulline malate or placebo in each crossover condition;Evaluation of 50 m split times

Countries

BR

Contacts

Public ContactSimone Pieniz

Universidade Federal de Pelotas

nutrisimone@yahoo.com.br+55-53-32843830

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026