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The Effect of a Protein Restricted Diet on Markers of Renal Function in Patients with Long-Term Renal Impairment Who are Undergoing Conservative Treatment

Effect of Low-Protein Diet on Renal Function Markers in Conservatively Treated Patients with Chronic Kidney Disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-5rf37wv
Enrollment
Unknown
Registered
2025-02-05
Start date
2025-02-05
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Failure

Interventions

This is a randomized clinical trial according to Body Mass Index (BMI), gender and Glomerular Filtration Rate (GFR) in patients with Chronic Kidney Disease (CKD) in the pre-dialysis phase (G3b-G5 with
after 1 month, the patient will return to the outpatient clinic to undergo the dietary survey, anthropometry, and we will verify adherence to the diet
There will be another return to the outpatient clinic after 6 mo
E02.642.249

Sponsors

Hospital Universitário Lauro Wanderley da Universidade Federal da Paraíba
Lead Sponsor
Universidade Federal da Paraíba
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients 18 years of age and older treated at the Nephrology Outpatient Clinic of the Lauro Wanderley University Hospital; Chronic Kidney Disease stage 3B to 5 not on dialysis; Glomerular filtration rate between 14-60 mL/minute; Male and female

Exclusion criteria

Exclusion criteria: Patients with chronic kidney disease due to autoimmune disease; Transplant recipients; Polycystic kidney disease; Renal neoplasia or single kidney disease; Liver Disease; Human Immunodeficiency Virus Carriers; Smokers; Pregnant women; Patients using dietary supplements such as probiotics, prebiotics, symbiotics, and antioxidants

Design outcomes

Primary

MeasureTime frame
Improvement in renal function in patients on a low protein diet (GFR and serum creatinine) for both diets when comparing baseline at the end of the study—

Secondary

MeasureTime frame
Decreased plasma concentrations of markers of inflammation, oxidative stress and uremic toxins (antioxidant enzymes glutathione peroxidase, superoxide dismutase and catalase and uremic toxins indoxyl sulfate, p-cresyl sulfate and indole-3-acetic acid) and improved cardiovascular parameters (autonomic function) for both diets when comparing baseline at the end of the study—

Countries

Brazil

Contacts

Public ContactPietra Pereira de Lima

Universidade Federal da Paraíba

pietrampl20@gmail.com+55 (83) 32167175

Outcome results

None listed

Source: REBEC (via WHO ICTRP)