Alzheimers disease
Conditions
Interventions
- Training group: the training group included the number of 18 participantes that underwent to aerobic exercise protocol. The aerobic training protocol was performed on a treadmill, three times a week
Other
G11.427.410.698.277
Sponsors
Unesp - Universidade estadual paulista
Ufabc - Universidade federal do ABC
Eligibility
Age
60 Years to 95 Years
Inclusion criteria
Inclusion criteria: Older adults over 60 years of age, of both sexes; Older adults with clinical diagnosis of Alzheimer's disease, Level of mild dementia severity according to the Clinical Dementia Rating Score (CDR) (MORRIS, 1993; MONTAÑO; RAMOS, 2005). The adoption of this criterion is due to the nature of the specific procedures of the proposed physical exercise intervention protocol, which requires a certain level of understanding of the activities by the elderly. Availability to participate in the activities proposed by the researcher; Agree and sign the Free and Informed Consent Term based on Resolution 466/12 of the National Health Council.
Exclusion criteria
Exclusion criteria: Older adults with coronarian disease, cardiac arrhythmia, non-controlled hypertension and angina symptons or any restriction to physical activity; Older adults with visual, hearing, vertiginous syndrome non-corrected impairment impairment or another limitation that prejudices locomotion; Older adults with another neuropsychiatric condition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome result: Cognitive improvement after 12 weeks of aerobic training, verified by increase in 1 point of total score in each cognitive test, associated with reduced blood viscosity in 2 mPa.s measured by viscometer and increase of 40 ng/mL of circulating IGF-1 levels, measured by enzyme immunoassay in older adults with Alzheimer's disease. Data collected one week before the intervention and one week after the intervention. ;Outcome result: no significative chantes in cognitive function. The IGF-1 circulating levels was maintained after 12 weeks. The blood viscosity was not collected. | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome result: Improvement in aerobic fitness, measured by an incremental submaximal performancetest, performed in the treadmill. Increased in 10% of VO2 máximo, calculated by indirect equation. Data collected one week before intervention and one week after the intervention. ;Outcome found: Increase in aerobic fitness, measured by performance in submaximal incremental test, performed on a treadmill. Approximate 21% increase in maximum VO2, calculated by indirect formula, for the Training Group, only. Data collected one week before the intervention and one week after the intervention. | — |
Countries
Brazil
Contacts
Public ContactAngelica Stein
Unesp - Universidade estadual paulista
Outcome results
None listed